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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

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  • Anders Ø Petersen
  • Hanna Julienne
  • Tuulia Hyötyläinen
  • Partho Sen
  • Yong Fan
  • Helle Krogh Pedersen
  • Sirkku Jäntti
  • Tue H Hansen
  • Trine Nielsen
  • Torben Jørgensen
  • Torben Hansen
  • Pernille Neve Myers
  • H Bjørn Nielsen
  • S Dusko Ehrlich
  • Matej Orešič
  • Oluf Pedersen
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Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes.

Original languageEnglish
Article number13252
JournalScientific Reports
Volume11
Issue number1
Pages (from-to)13252
ISSN2045-2322
DOIs
Publication statusPublished - 24 Jun 2021

    Research areas

  • Adiposity, Bile Acids and Salts/blood, Body Mass Index, Cholic Acids/blood, Chromatography, High Pressure Liquid, Clostridium/genetics, Deoxycholic Acid/blood, Female, Gastrointestinal Microbiome/genetics, Humans, Logistic Models, Male, Metagenomics, Middle Aged, Obesity/blood, Tandem Mass Spectrometry, Taurocholic Acid/blood, Waist Circumference

ID: 72506423