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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy

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  • L.H. Jensen
  • R Altaf
  • H. Harling
  • M. Jensen
  • Solveig Laurberg
  • J.C. Lindegaard
  • A. Muhic
  • Lene Weber Vestermark
  • A. Jakobsen
  • S. Bulow
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Aim: The purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. Methods: Through a validated, prospective national database we identified 520 Danish patients who presented with high-risk mobile tumours in the lower two thirds of the rectum and were referred for preoperative radiotherapy with 5 x 5 Gy. The inclusion period was 56 months. Radiotherapy data was retrospectively collected. Results: Of the 520 patients, 514 completed radiotherapy and 506 had surgery. Surgery was considered curative in 439 patients. The 3-year local recurrence rate was 4.0% (95% CI 2.5-6.5%) and the distant recurrence rate at 3 years was 18.7% (95% CI 15.4-22.5%). The 5-year disease free survival rate was 40.2% (95% CI 27.0-53.1%) and overall survival 50.4% (95% CI 36.1-63.1%). Most tumours (61%) were classified as T3 or T4 and 41% of the local recurrences occurred in patients with a fixed tumour at surgery. Conclusion: This study confirms data from randomised studies that the shots course 5 x 5 Gy regime is a feasible treatment for locally advanced rectal cancer even when applied in a population outside clinical trials. (C) 2009 Elsevier Ltd. All rights reserved
Original languageEnglish
JournalEuropean Journal of Surgical Oncology
Volume36
Issue number3
Pages (from-to)237-243
Number of pages7
ISSN0748-7983
DOIs
Publication statusPublished - 2010

ID: 32251388