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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry

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DOI

  1. Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Upper Extremity DVT versus Lower Extremity DVT: Perspectives from the GARFIELD-VTE Registry

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Global Anticoagulant Registry in the Field - Venous Thromboembolism (GARFIELD-VTE). Rationale and design

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The management of thrombosis in pregnancy: role of low-molecular-weight heparin

    Research output: Contribution to journalReviewpeer-review

  1. Assessment of Outcomes Among Patients With Venous Thromboembolism With and Without Chronic Kidney Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Comparative effectiveness of oral anticoagulants in venous thromboembolism: GARFIELD-VTE

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Anticoagulation therapy patterns for acute treatment of venous thromboembolism in GARFIELD-VTE patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry

    Research output: Contribution to journalJournal articleResearchpeer-review

  • GARFIELD-VTE investigators
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BACKGROUND:  Management of venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), varies worldwide.

METHODS:  The Global Anticoagulant Registry in the FIELD - Venous Thromboembolism (GARFIELD-VTE) is a prospective, observational study of 10,685 patients with objectively diagnosed VTE recruited from May 2014 to January 2017 at 417 sites in 28 countries. All patients are followed for at least 3 years. We describe the baseline characteristics of the study population and their management within 30 days of diagnosis.

RESULTS:  The median age was 60.2 years; 50.4% were male; 61.7% had DVT and 38.3% had PE ± DVT; and 32.3% were obese (body mass index ≥ 30 kg/m2). The most common risk factors were surgery (12.5%), hospitalization (12.0%) and trauma to the lower limbs (7.8%). At the time of VTE diagnosis, 10.1% had active cancer and 5.7% were chronically immobilized. Treatment for VTE was anticoagulant (AC) therapy alone in 90.9% of patients; 5.1% received thrombolytic and/or surgical/mechanical therapy ± AC and 4.0% received no therapy. Pre-diagnosis, 12.8% received AC therapy alone and 0.2% received thrombolytic and/or surgical/mechanical therapy ± AC. After diagnosis, parenteral AC therapy alone was administered in 17.6% of patients, and it was followed by a direct oral AC (DOAC) in 16.4% or a vitamin K antagonist (VKA) in 26.8%. DOACs alone were prescribed to 32.3% of patients, while 5.9% received VKA alone.

CONCLUSION:  The initial findings from this global registry highlight the heterogeneity in characteristics and management of VTE patients. Prospective follow-up will reveal the impact of this heterogeneity on outcomes.

Original languageEnglish
JournalThrombosis and Haemostasis
Volume119
Issue number2
Pages (from-to)319-327
Number of pages9
ISSN0340-6245
DOIs
Publication statusPublished - Feb 2019

    Research areas

  • Aged, Anticoagulants/therapeutic use, Cardiology/methods, Comorbidity, Female, Global Health, Hospitalization, Humans, International Cooperation, Male, Middle Aged, Pulmonary Embolism/epidemiology, Registries, Venous Thromboembolism/epidemiology, Venous Thrombosis/epidemiology

ID: 61882787