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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Ceramides and barrier function in healthy skin

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DOI

  1. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

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  2. Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process

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  3. Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study

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  1. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

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  2. Atopic dermatitis is associated with increased use of social benefits: a register-based cohort study

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  3. The epidemic of methylisothiazolinone contact allergy in Europe: follow-up on changing exposures

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  4. Risk of work-related hand eczema in relation to wet work exposure

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  5. Factors influencing the prognosis for occupational hand eczema - new trends: new trends

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Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).
Original languageEnglish
JournalActa Dermato Venereologica
Volume90
Issue number4
Pages (from-to)350-3
Number of pages4
ISSN0001-5555
DOIs
Publication statusPublished - 1 Jul 2010

ID: 32331070