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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Cardiorespiratory fitness and physical performance after childhood hematopoietic stem cell transplantation: a systematic review and meta-analysis

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  • Martin Kaj Fridh
  • Casper Simonsen
  • Peter Schmidt-Andersen
  • Anne Anker Nissen
  • Jesper Frank Christensen
  • Anders Larsen
  • Abigail L Mackey
  • Hanne Bækgaard Larsen
  • Klaus Müller
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The effects of childhood hematopoietic stem cell transplantation (HSCT) on key organs can impair cardiorespiratory fitness, muscle strength, and physical performance. We aimed to provide an overview of childhood HSCT survivors' status on these parameters compared with healthy controls and discuss current insights into clinical risk factors. We performed a systematic search in six scientific databases, including studies published before April 2019 and performed a meta-analysis on cardiorespiratory fitness. Muscle strength and physical performance status were presented narratively. We included ten studies embodying 517 childhood HSCT survivors (mean 17.8 years at follow-up). The meta-analysis (n = 4 studies) showed that childhood HSCT survivors have lower cardiorespiratory fitness compared with healthy controls (Standard mean difference (SMD) -1.32 [95% CI -1-58 to -1.07]; I2 2%, p < 0.00001). Collectively, the studies indicated that childhood HSCT survivors have lower muscle strength (n = 4 studies) and physical performance (n = 3 studies) compared with healthy controls. Childhood HSCT survivors have impaired cardiorespiratory fitness years after ended treatment. Muscle strength and physical performance seem to be impaired, although these measures are insufficiently investigated. Associations between HSCT-specific clinical risk factors and cardiorespiratory fitness, muscle strength, and physical performance are required.

Original languageEnglish
JournalBone Marrow Transplantation
Volume56
Issue number9
Pages (from-to)2063-2078
Number of pages16
ISSN0268-3369
DOIs
Publication statusPublished - Sep 2021

ID: 66432795