Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Bacterial infections in alcoholic and nonalcoholic liver cirrhosis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Letter to the Editor

    Research output: Contribution to journalComment/debateResearch

  2. Symptoms and biomarkers associated with celiac disease: evaluation of a population-based screening program in adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Quality of life assessment among patients with peristomal skin disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis: A multicentre study of 1117 cases

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. dredning, opfølgning og behandling af cyster i pancreas

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Chronic Pancreatitis Is Characterized by Distinct Complication Clusters That Associate With Etiological Risk Factors

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: Longitudinal, population-based data on the occurrence, localization, and severity of bacterial infections over time in patients with alcoholic compared with nonalcoholic cirrhosis are limited.

MATERIALS AND METHODS: All patients with incident cirrhosis diagnosed in 2001-2010 (area of 600,000 inhabitants) were retrospectively identified. All bacterial infections resulting in or occurring during an inpatient hospital episode during this period were registered. The etiology of cirrhosis (alcoholic vs. nonalcoholic), infection localization, and outcome as well as bacterial resistance patterns were analyzed. Patients were followed until death, transplant, or the end of 2011.

RESULTS: In all, 633 cirrhotics (363 alcoholic, 270 nonalcoholic) experienced a total of 398 infections (2276 patient-years). Among patients diagnosed with cirrhosis each year from 2001 to 2010, increasing trends were noted in the occurrence of infection (from 13 to 27%, P<0.001) and infection-related in-hospital mortality (from 2 to 7%, P=0.05), the latter mainly in the alcoholic group. Although alcoholic etiology was related to the occurrence of more frequent infection (Kaplan-Meier, P<0.001), this relationship was not significant after adjustment for confounders in Cox regression analysis (P=0.056). Resistance to piperacilin-tazobactam and carbapenems was more common in infections occurring in alcoholic versus nonalcoholic cirrhosis (13 vs. 5%, P=0.057 and 12 vs. 2%, P=0.009). Alcoholic etiology predicted pneumonia and infections caused by Gram-positive bacteria in multivariate analysis (P<0.05 for both).

CONCLUSION: In a population-based cirrhotic cohort, bacterial infections increased over time, which, in the case of alcoholic cirrhosis, was associated with pneumonia and bacterial resistance to antibiotics. However, alcoholic etiology was not related indepedently to the occurrence of bacterial infections.

Original languageEnglish
JournalEuropean journal of gastroenterology & hepatology
Volume27
Issue number9
Pages (from-to)1080-6
Number of pages7
ISSN0954-691X
DOIs
Publication statusPublished - Sep 2015

    Research areas

  • Aged, Anti-Bacterial Agents, Bacterial Infections, Drug Resistance, Bacterial, Female, Humans, Incidence, Kaplan-Meier Estimate, Liver Cirrhosis, Liver Cirrhosis, Alcoholic, Liver Transplantation, Logistic Models, Male, Middle Aged, Multivariate Analysis, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Sweden, Time Factors, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

ID: 50645953