Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Asymptomatic carriers contribute to nosocomial Clostridium difficile infection: a cohort study of 4508 patients

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Cancer Risk in Pediatric-Onset Inflammatory Bowel Disease: A Population-Based Danish Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Remission of bile acid malabsorption symptoms following treatment with the glucagon-like peptide 1 receptor agonist liraglutide

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Reply

    Research output: Contribution to journalComment/debateResearchpeer-review

  1. The Incidence and Disease Course of Perianal Crohn's Disease: A Danish Nationwide Cohort Study, 1997-2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exposome and diet

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  3. Relation between NOD2 genotype and changes in innate signaling in Crohn's disease on mRNA and miRNA levels

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND & AIMS: Nosocomial infection with Clostridium difficile pose a considerable problem despite numerous attempts by health care workers to reduce risk of transmission. Asymptomatic carriers of C difficile might spread their infection to other patients. We investigated the effects of of asymptomatic carriers on nosocomial C difficile infections.

METHODS: We performed a population-based prospective cohort study at 2 university hospitals in Denmark, screening all patients for toxigenic C difficile in the intestine upon admittance, from October 1, 2012, to January 31, 2013. Screening results were blinded to patients, staff, and researchers. Patients were followed during their hospital stay by daily registration of wards and patient rooms. The primary outcomes were rate of C difficile infection in exposed and unexposed patients and factors associated with transmission.

RESULTS: C difficile infection was detected in 2.6% of patients not exposed to carriers and in 4.6% of patients exposed to asymptomatic carriers, at the ward level (odds ratio for infection if exposed to carrier, 1.79; 95% CI, 1.16-2.76). Amount of exposure correlated with risk of C difficile infection, from 2.2% in the lowest quartile to 4.2% in the highest quartile of exposed patients (P=.026). Combining the load of exposure to carriers and length of stay seemed to have an additive effect on the risk of contracting C difficile.

CONCLUSIONS: In a population-based prospective cohort study in Denmark, we found that asymptomatic carriers of toxigenic C difficile in hospitals increase risk of infection in other patients.

Original languageEnglish
JournalGastroenterology
Volume152
Issue number5
Pages (from-to)1031-1041
ISSN0016-5085
DOIs
Publication statusPublished - 1 Apr 2017

ID: 49610470