Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Association of the intraoperative peripheral perfusion index with postoperative morbidity and mortality in acute surgical patients: a retrospective observational multicentre cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Sphenopalatine ganglion block for the treatment of postdural puncture headache in paediatric patients

    Research output: Contribution to journalLetterResearchpeer-review

  2. Sphenopalatine ganglion block for the treatment of postdural puncture headache: a randomised, blinded, clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Perioperative hyperoxia: why guidelines, research and clinical practice collide

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Benefit and harm of pregabalin in acute pain treatment: a systematic review with meta-analyses and trial sequential analyses

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. High intraoperative inspiratory oxygen fraction and risk of major respiratory complications

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Agreement Between Transcutaneous Monitoring and Arterial Blood Gases During COPD Exacerbation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Association between tissue oxygenation and myocardial injury in patients undergoing major spine surgery: a prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Live video from bystanders' smartphones to improve cardiopulmonary resuscitation

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Live video from bystanders' smartphones to medical dispatchers in real emergencies

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Marianne Agerskov
  • Anna N W Thusholdt
  • Henrik Holm-Sørensen
  • Sebastian Wiberg
  • Christian S Meyhoff
  • Jakob Højlund
  • Niels H Secher
  • Nicolai B Foss
View graph of relations

Background: We hypothesised that in acute high-risk surgical patients, a lower intraoperative peripheral perfusion index (PPI) would indicate a higher risk of postoperative complications and mortality. Methods: This retrospective observational study included 1338 acute high-risk surgical patients from November 2017 until October 2018 at two University Hospitals in Denmark. Intraoperative PPI was the primary exposure variable and the primary outcome was severe postoperative complications defined as a Clavien–Dindo Class ≥III or death, within 30 days. Results: intraoperative PPI was associated with severe postoperative complications or death: odds ratio (OR) 1.12 (95% confidence interval [CI] 1.05–1.19; P<0.001), with an association of intraoperative mean PPI ≤0.5 and PPI ≤1.5 with the primary outcome: OR 1.79 (95% CI 1.09–2.91; P=0.02) and OR 1.65 (95% CI 1.20–2.27; P=0.002), respectively. Each 15-min increase in intraoperative time spend with low PPI was associated with the primary outcome (per 15 min with PPI ≤0.5: OR 1.11 (95% CI 1.05–1.17; P<0.001) and with PPI ≤1.5: OR 1.06 (95% CI 1.02–1.09; P=0.002)). Thirty-day mortality in patients with PPI ≤0.5 was 19% vs 10% for PPI >0.5, P=0.003. If PPI was ≤1.5, 30-day mortality was 16% vs 8% in patients with a PPI >1.5 (P<0.001). In contrast, intraoperative mean MAP ≤65 mm Hg was not significantly associated with severe postoperative complications or death (OR 1.21 [95% CI 0.92–1.58; P=0.2]). Conclusions: Low intraoperative PPI was associated with severe postoperative complications or death in acute high-risk surgical patients. To guide intraoperative haemodynamic management, the PPI should be further investigated.

Original languageEnglish
JournalBritish Journal of Anaesthesia
Volume127
Issue number3
Pages (from-to)396-404
Number of pages9
ISSN0007-0912
DOIs
Publication statusPublished - Sep 2021

    Research areas

  • cardiac output, clinical monitoring, gold-directed therapy, haemodynamics, peripheral perfusion index, postoperative complications, surgery

ID: 66571691