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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Applied mediation analyses: a review and tutorial

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  1. Too sick to work, too healthy to qualify: a cross-country analysis of the effect of changes to disability benefits

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  2. Intelligence in early adulthood and mortality from natural and unnatural causes in middle-aged Danish men

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  1. Early diastolic strain rate in relation to long term prognosis following isolated coronary artery bypass grafting

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  2. Association of fatal myocardial infarction with past level of physical activity: a pooled analysis of cohort studies

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  3. Change in global longitudinal strain following acute coronary syndrome and subsequent risk of heart failure

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  4. Left ventricular end-diastolic pressure is associated with left atrial functional measures by echocardiography

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In recent years, mediation analysis has emerged as a powerful tool to disentangle causal pathways from an exposure/treatment to clinically relevant outcomes. Mediation analysis has been applied in scientific fields as diverse as labour market relations and randomized clinical trials of heart disease treatments. In parallel to these applications, the underlying mathematical theory and computer tools have been refined. This combined review and tutorial will introduce the reader to modern mediation analysis including: the mathematical framework; required assumptions; and software implementation in the R package medflex. All results are illustrated using a recent study on the causal pathways stemming from the early invasive treatment of acute coronary syndrome, for which the rich Danish population registers allow us to follow patients' medication use and more after being discharged from hospital.

Original languageEnglish
JournalJournal of Epidemiology & Community Health
Volume39
Pages (from-to)e2017035
ISSN0143-005X
DOIs
Publication statusPublished - 2017

    Research areas

  • Acute Coronary Syndrome, Denmark, Humans, Outcome Assessment (Health Care), Patient Discharge, Randomized Controlled Trials as Topic, Registries, Journal Article, Review

ID: 52610512