Research
Print page Print page
Switch language
Bispebjerg Hospital - a part of Copenhagen University Hospital
Published

Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Predictive Importance of Blood Pressure Characteristics With Increasing Age in Healthy Men and Women: The MORGAM Project

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Taking no for an answer. Nurses' consultations with people with cardiac disease about rehabilitation: A qualitative study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Dora Csengeri
  • Ngoc-Anh Sprünker
  • Augusto Di Castelnuovo
  • Teemu Niiranen
  • Julie Kk Vishram-Nielsen
  • Simona Costanzo
  • Stefan Söderberg
  • Steen M Jensen
  • Erkki Vartiainen
  • Maria Benedetta Donati
  • Christina Magnussen
  • Stephan Camen
  • Francesco Gianfagna
  • Maja-Lisa Løchen
  • Frank Kee
  • Jukka Kontto
  • Ellisiv B Mathiesen
  • Wolfgang Koenig
  • Blankenberg Stefan
  • Giovanni de Gaetano
  • Torben Jørgensen
  • Kari Kuulasmaa
  • Tanja Zeller
  • Veikko Salomaa
  • Licia Iacoviello
  • Renate B Schnabel
View graph of relations

AIMS : There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.

METHODS AND RESULTS : In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF.

CONCLUSIONS : In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.

Original languageEnglish
JournalEuropean Heart Journal
Volume42
Issue number12
Pages (from-to)1170-1177
Number of pages8
ISSN0195-668X
DOIs
Publication statusPublished - 21 Mar 2021

ID: 61779847