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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Agreement Between Transcutaneous Monitoring and Arterial Blood Gases During COPD Exacerbation

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@article{90bf37501d4e47e093ccb3dfd4b37891,
title = "Agreement Between Transcutaneous Monitoring and Arterial Blood Gases During COPD Exacerbation",
abstract = "BACKGROUND: Transcutaneous measurements of CO2 and O2 ([Formula: see text], [Formula: see text]) are noninvasive and allow for continuous monitoring in adults with exacerbation of COPD, but substantial accuracy issues may exist. We investigated agreement between results of arterial blood gas analysis and transcutaneous measurements of CO2 and O2 in patients with COPD.METHODS: Adult subjects were monitored after acute admission to a respiratory intermediate care unit or ICU due to exacerbation of COPD and with ongoing noninvasive ventilation or immediately following extubation. Monitored variables were continuous transcutaneous measurement and simultaneous routine arterial blood gas analysis. Agreement between measurements was assessed by calculating bias with 95% limits of agreement for single-point estimates of [Formula: see text] versus [Formula: see text] and versus [Formula: see text], and for changes in transcutaneous measurements between 2 time points ([Formula: see text] and [Formula: see text]). We considered limits of agreement within ± 7.5 mm Hg to be acceptable.RESULTS: A total of 57 transcutaneous measurements were made in 20 subjects for comparison with concurrent arterial blood gas analysis at 36 time points. The bias (limits of agreement) for [Formula: see text] and [Formula: see text] was 2.5 mm Hg (-10.6 to 15.6 mm Hg) and 11.2 mm Hg (-28.2 to 50.6 mm Hg), respectively. The bias for [Formula: see text] and [Formula: see text] was 2.3 mm Hg (-3.8 to 8.3 mm Hg) and -5.3 mm Hg (-37.5 to 27 mm Hg), respectively.CONCLUSIONS: [Formula: see text] and [Formula: see text] did not accurately reflect results from arterial blood gas analyses in this study of mostly hypercapnic subjects. Agreement between changes in CO2 during the monitoring period was acceptable, however, and transcutaneous monitoring may be used for continuous monitoring of [Formula: see text] in conjunction with arterial blood gas analysis for reference.",
keywords = "Adult, Blood Gas Monitoring, Transcutaneous, Carbon Dioxide, Humans, Hypercapnia, Noninvasive Ventilation, Pulmonary Disease, Chronic Obstructive, Intensive care, Transcutaneous blood gas monitoring, Noninvasive ventilation, Respiratory insuffi-ciency, COPD",
author = "S{\o}rensen, {Kasper M} and Leicht, {Rebecca V} and Carlsson, {Christian J} and Mikkel Elvekjaer and Celeste Porsbjerg and Aasvang, {Eske K} and Meyhoff, {Christian S}",
note = "Copyright {\textcopyright} 2021 by Daedalus Enterprises.",
year = "2021",
month = oct,
doi = "10.4187/respcare.08510",
language = "English",
volume = "66",
pages = "1560--1566",
journal = "Respiratory Care",
issn = "0020-1324",
publisher = "Daedalus Enterprises, Inc",
number = "10",

}

RIS

TY - JOUR

T1 - Agreement Between Transcutaneous Monitoring and Arterial Blood Gases During COPD Exacerbation

AU - Sørensen, Kasper M

AU - Leicht, Rebecca V

AU - Carlsson, Christian J

AU - Elvekjaer, Mikkel

AU - Porsbjerg, Celeste

AU - Aasvang, Eske K

AU - Meyhoff, Christian S

N1 - Copyright © 2021 by Daedalus Enterprises.

PY - 2021/10

Y1 - 2021/10

N2 - BACKGROUND: Transcutaneous measurements of CO2 and O2 ([Formula: see text], [Formula: see text]) are noninvasive and allow for continuous monitoring in adults with exacerbation of COPD, but substantial accuracy issues may exist. We investigated agreement between results of arterial blood gas analysis and transcutaneous measurements of CO2 and O2 in patients with COPD.METHODS: Adult subjects were monitored after acute admission to a respiratory intermediate care unit or ICU due to exacerbation of COPD and with ongoing noninvasive ventilation or immediately following extubation. Monitored variables were continuous transcutaneous measurement and simultaneous routine arterial blood gas analysis. Agreement between measurements was assessed by calculating bias with 95% limits of agreement for single-point estimates of [Formula: see text] versus [Formula: see text] and versus [Formula: see text], and for changes in transcutaneous measurements between 2 time points ([Formula: see text] and [Formula: see text]). We considered limits of agreement within ± 7.5 mm Hg to be acceptable.RESULTS: A total of 57 transcutaneous measurements were made in 20 subjects for comparison with concurrent arterial blood gas analysis at 36 time points. The bias (limits of agreement) for [Formula: see text] and [Formula: see text] was 2.5 mm Hg (-10.6 to 15.6 mm Hg) and 11.2 mm Hg (-28.2 to 50.6 mm Hg), respectively. The bias for [Formula: see text] and [Formula: see text] was 2.3 mm Hg (-3.8 to 8.3 mm Hg) and -5.3 mm Hg (-37.5 to 27 mm Hg), respectively.CONCLUSIONS: [Formula: see text] and [Formula: see text] did not accurately reflect results from arterial blood gas analyses in this study of mostly hypercapnic subjects. Agreement between changes in CO2 during the monitoring period was acceptable, however, and transcutaneous monitoring may be used for continuous monitoring of [Formula: see text] in conjunction with arterial blood gas analysis for reference.

AB - BACKGROUND: Transcutaneous measurements of CO2 and O2 ([Formula: see text], [Formula: see text]) are noninvasive and allow for continuous monitoring in adults with exacerbation of COPD, but substantial accuracy issues may exist. We investigated agreement between results of arterial blood gas analysis and transcutaneous measurements of CO2 and O2 in patients with COPD.METHODS: Adult subjects were monitored after acute admission to a respiratory intermediate care unit or ICU due to exacerbation of COPD and with ongoing noninvasive ventilation or immediately following extubation. Monitored variables were continuous transcutaneous measurement and simultaneous routine arterial blood gas analysis. Agreement between measurements was assessed by calculating bias with 95% limits of agreement for single-point estimates of [Formula: see text] versus [Formula: see text] and versus [Formula: see text], and for changes in transcutaneous measurements between 2 time points ([Formula: see text] and [Formula: see text]). We considered limits of agreement within ± 7.5 mm Hg to be acceptable.RESULTS: A total of 57 transcutaneous measurements were made in 20 subjects for comparison with concurrent arterial blood gas analysis at 36 time points. The bias (limits of agreement) for [Formula: see text] and [Formula: see text] was 2.5 mm Hg (-10.6 to 15.6 mm Hg) and 11.2 mm Hg (-28.2 to 50.6 mm Hg), respectively. The bias for [Formula: see text] and [Formula: see text] was 2.3 mm Hg (-3.8 to 8.3 mm Hg) and -5.3 mm Hg (-37.5 to 27 mm Hg), respectively.CONCLUSIONS: [Formula: see text] and [Formula: see text] did not accurately reflect results from arterial blood gas analyses in this study of mostly hypercapnic subjects. Agreement between changes in CO2 during the monitoring period was acceptable, however, and transcutaneous monitoring may be used for continuous monitoring of [Formula: see text] in conjunction with arterial blood gas analysis for reference.

KW - Adult

KW - Blood Gas Monitoring, Transcutaneous

KW - Carbon Dioxide

KW - Humans

KW - Hypercapnia

KW - Noninvasive Ventilation

KW - Pulmonary Disease, Chronic Obstructive

KW - Intensive care

KW - Transcutaneous blood gas monitoring

KW - Noninvasive ventilation

KW - Respiratory insuffi-ciency

KW - COPD

UR - http://www.scopus.com/inward/record.url?scp=85116665705&partnerID=8YFLogxK

U2 - 10.4187/respcare.08510

DO - 10.4187/respcare.08510

M3 - Journal article

C2 - 34074743

VL - 66

SP - 1560

EP - 1566

JO - Respiratory Care

JF - Respiratory Care

SN - 0020-1324

IS - 10

ER -

ID: 65947890