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Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium

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Harvard

Morseth, B, Geelhoed, B, Linneberg, A, Johansson, L, Kuulasmaa, K, Salomaa, V, Iacoviello, L, Costanzo, S, Söderberg, S, Niiranen, TJ, Vishram-Nielsen, JKK, Njølstad, I, Wilsgaard, T, Mathiesen, EB, Løchen, M-L, Zeller, T, Blankenberg, S, Ojeda, FM, Schnabel, RB & MORGAM consortium 2021, 'Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium', Open Heart, vol. 8, no. 2, e001624, pp. e001624. https://doi.org/10.1136/openhrt-2021-001624

APA

Morseth, B., Geelhoed, B., Linneberg, A., Johansson, L., Kuulasmaa, K., Salomaa, V., Iacoviello, L., Costanzo, S., Söderberg, S., Niiranen, T. J., Vishram-Nielsen, J. K. K., Njølstad, I., Wilsgaard, T., Mathiesen, E. B., Løchen, M-L., Zeller, T., Blankenberg, S., Ojeda, F. M., Schnabel, R. B., & MORGAM consortium (2021). Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium. Open Heart, 8(2), e001624. [e001624]. https://doi.org/10.1136/openhrt-2021-001624

CBE

Morseth B, Geelhoed B, Linneberg A, Johansson L, Kuulasmaa K, Salomaa V, Iacoviello L, Costanzo S, Söderberg S, Niiranen TJ, Vishram-Nielsen JKK, Njølstad I, Wilsgaard T, Mathiesen EB, Løchen M-L, Zeller T, Blankenberg S, Ojeda FM, Schnabel RB, MORGAM consortium. 2021. Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium. Open Heart. 8(2):e001624. https://doi.org/10.1136/openhrt-2021-001624

MLA

Vancouver

Author

Morseth, Bente ; Geelhoed, Bastiaan ; Linneberg, Allan ; Johansson, Lars ; Kuulasmaa, Kari ; Salomaa, Veikko ; Iacoviello, Licia ; Costanzo, Simona ; Söderberg, Stefan ; Niiranen, Teemu J ; Vishram-Nielsen, Julie K K ; Njølstad, Inger ; Wilsgaard, Tom ; Mathiesen, Ellisiv B ; Løchen, Maja-Lisa ; Zeller, Tanja ; Blankenberg, Stefan ; Ojeda, Francisco M ; Schnabel, Renate B ; MORGAM consortium. / Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality : results from the MORGAM Consortium. In: Open Heart. 2021 ; Vol. 8, No. 2. pp. e001624.

Bibtex

@article{4824af62cb5642ec82081563238888c6,
title = "Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium",
abstract = "BACKGROUND: The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age.METHODS: We used individual-level data (n=66 951, 49.1% men, age range 40-98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF.RESULTS: AF incidence increased from 0.9 per 1000 person-years at baseline age 40-49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001).CONCLUSION: In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life.",
keywords = "atrial fibrillation, epidemiology, risk factors, stroke",
author = "Bente Morseth and Bastiaan Geelhoed and Allan Linneberg and Lars Johansson and Kari Kuulasmaa and Veikko Salomaa and Licia Iacoviello and Simona Costanzo and Stefan S{\"o}derberg and Niiranen, {Teemu J} and Vishram-Nielsen, {Julie K K} and Inger Nj{\o}lstad and Tom Wilsgaard and Mathiesen, {Ellisiv B} and Maja-Lisa L{\o}chen and Tanja Zeller and Stefan Blankenberg and Ojeda, {Francisco M} and Schnabel, {Renate B} and {MORGAM consortium}",
note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = jul,
doi = "10.1136/openhrt-2021-001624",
language = "English",
volume = "8",
pages = "e001624",
journal = "Open Heart",
issn = "2053-3624",
publisher = "BMJ Publishing Group",
number = "2",

}

RIS

TY - JOUR

T1 - Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality

T2 - results from the MORGAM Consortium

AU - Morseth, Bente

AU - Geelhoed, Bastiaan

AU - Linneberg, Allan

AU - Johansson, Lars

AU - Kuulasmaa, Kari

AU - Salomaa, Veikko

AU - Iacoviello, Licia

AU - Costanzo, Simona

AU - Söderberg, Stefan

AU - Niiranen, Teemu J

AU - Vishram-Nielsen, Julie K K

AU - Njølstad, Inger

AU - Wilsgaard, Tom

AU - Mathiesen, Ellisiv B

AU - Løchen, Maja-Lisa

AU - Zeller, Tanja

AU - Blankenberg, Stefan

AU - Ojeda, Francisco M

AU - Schnabel, Renate B

AU - MORGAM consortium

N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/7

Y1 - 2021/7

N2 - BACKGROUND: The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age.METHODS: We used individual-level data (n=66 951, 49.1% men, age range 40-98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF.RESULTS: AF incidence increased from 0.9 per 1000 person-years at baseline age 40-49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001).CONCLUSION: In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life.

AB - BACKGROUND: The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age.METHODS: We used individual-level data (n=66 951, 49.1% men, age range 40-98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF.RESULTS: AF incidence increased from 0.9 per 1000 person-years at baseline age 40-49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001).CONCLUSION: In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life.

KW - atrial fibrillation

KW - epidemiology

KW - risk factors

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85112007774&partnerID=8YFLogxK

U2 - 10.1136/openhrt-2021-001624

DO - 10.1136/openhrt-2021-001624

M3 - Journal article

C2 - 34341095

VL - 8

SP - e001624

JO - Open Heart

JF - Open Heart

SN - 2053-3624

IS - 2

M1 - e001624

ER -

ID: 67382936