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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

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  • Vicente Mustieles
  • Francisco M Pérez-Carrascosa
  • Josefa León
  • Theis Lange
  • Jens-Peter Bonde
  • Celia Gómez-Peña
  • Francisco Artacho-Cordón
  • Rocío Barrios-Rodríguez
  • Rocío Olmedo-Requena
  • José Expósito
  • José J Jiménez-Moleón
  • Juan P Arrebola
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We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003-2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT's oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.

Original languageEnglish
JournalEnvironmental Science & Technology
Volume55
Issue number14
Pages (from-to)9926-9937
Number of pages12
ISSN0013-936X
DOIs
Publication statusPublished - 20 Jul 2021

    Research areas

  • Adipose Tissue/metabolism, Adult, Environmental Pollutants/metabolism, Humans, Hydrocarbons, Chlorinated/metabolism, Incidence, Neoplasms/chemically induced, Oxidation-Reduction, Persistent Organic Pollutants, Pesticides/metabolism, Polychlorinated Biphenyls/metabolism, Tumor Microenvironment, organochlorine pesticides, polychlorinated biphenyls, persistent organic pollutants, cancer, oxidative stress

ID: 67050803