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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Mikkel Bring Christensen

MD PhD

  • Clinical Pharmacology, Department of
Postal address:
Denmark

Email: Mikkel.Bring.Christensen@regionh.dk

Education

2004: Master of Medicine, University of Copenhagen, Denmark and authorization as a physician; 2006: Permission to practice independently as a physician (full registration); 2013: Specialist in Clinical Pharmacology (aut. ID: 05HN6), The Danish National Board of Health; 2014: PhD in health science (Thesis ISBN: 978-87-92613-44-8), University of Copenhagen; 2016: Leadership Programme (6 modules, 14 days)), Capital Region of Denmark: 2021: Research Management Course (6 modules, 9½ days), CBS Executive Fonden.

Employment History

2004: Resident, Department of Internal Medicin, Koege Hospital, University of Copenhagen, Denmark; 2004-2005: Resident, Department of Orthopedic Surgery, Koege Hospital, University of Copenhagen, Denmark; 2005-2005: GP resident, Solroed Strand, Denmark; 2006-2007: Several short term GP resident positions, Various places in Norway; 2006-2007: Resident physician, Department of Internal Medicine F, Gentofte Hospital University of Copenhagen, Denmark; 2007-2008: Resident physician, Department of Internal Medicine, Amager Hospital University of Copenhagen, Denmark; 2007-2008: Physician, Senior Resident, Department of Clinical Pharmacology, Bispebjerg Hospital,University of Copenhagen, Denmark; 2008-2016: Medical Expert in authorization of medicinal products (10 hours weekly), Danish Medicines Agency; 2009-2010: Clinical Research Assistant, Center for Diabetes Research, Gentofte University Hospital; 2010: Physician, Senior Resident, Department of Hematology, Rigshospitalet, University of Copenhagen, Denmark; 2010-2012: Clinical Research Assistant, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Denmark; 2012-2013: Physician, Senior Resident, Department of Clinical Pharmacology, Bispebjerg Hospital; 2013-2013: Physician, Senior Resident, Department of Internal Medicine, Gentofte Hospital; 2013-present: Chief Physician, Head of Education, Department of Clinical Pharmacology, Bispebjerg Hospital; 2013-present: Clinical Associate Professor, University of Copenhagen and Bispebjerg Hospital; 2018-present: Postgraduate Associate Professor, Eastern Region of Denmark & University of Copenhagen; 2020-present: Head of Copenhagen Centre for Translationel Research, Bispebjerg and Frederiksberg Hospital.

Current Positions

Head of Copenhagen Centre for Translational Research (60% position at Department of Biochemistry Bispebjerg and Frederiksberg Hospital) & Chief Physician and Clinical Associate Professor (40% position at at the Department of Clinical Pharmacology, Bispebjerg Hospital). Responsibilities include Research management of translational research and phase one clinical trials (Zelo Phase one trial unit), medication reviews at outpatient clinics, function as a clinical toxicologist on-call at the national poison information center (Giftlinjen).

Honorary Positions

Dr. Mikkel Christensen is involved in several national and regional councils that evaluate pharmacotherapy and thereby impact rational use of medicines in Denmark. Ongoing from 2014: Chairman of the endocrinology group by the Capital Region’s Medicines Committee (Den Regionale Lægemiddelkomite). Ongoing from 2016: Part of working group National Recommendation List (Den Nationale Rekommandationsliste) from the Danish Health Authority (Sundhedsstyrelsen) appointed by Danish Society of Clinical Pharmacology. From 2019: Member of the national Danish Medicines Council (Medicinrådet) “workgroup on type 2 diabetes” appointed by Danish Society of Clinical Pharmacology.

Recent Selected Awards and Grants

Awards: Awarded talent price from the Bagger-Sørensen foundation (2015), Young investigator of the year, Scandinavian Society for the Study of Diabetes (2012); Grants: Research grants from the Capital region of Denmark, University of Copenhagen, Danish Diabetes Association, Beckett-foundation and Tryg Foundation - total funding amounting to > € 2,000,000.

Publications, Citations and H-Indices

Research primarily within the areas: Clinical pharmacology, polypharmacy, medication review, diabetology, and medicines safety/toxicology (see full publication list on Google Scholar: Mikkel Christensen). Author of several textbook chapters and >120 scientific publications (68 original articles, 34 scientific reviews/proceedings, 25 commentaries/editorials/letters/case reports). >100 Danish and international scientific presentations. Impact Citations: ~ Citations: ~ 4279 (Google Scholar), ~2.671 (Web of Science). H-indices: 30 (Google Scholar), 29 (Web of Science); Scopus Author ID: 32067543900; ResearcherID: H-5861-2013; https://orcid.org/0000-0002-8774-1797

Supervising, Evaluation and Teaching Experience

Supervisor for 17 PhD students - 4 as primary supervisor (1 completed) and 13 as co-supervisor (4 completed) in clinical pharmacology, metabolism and toxicology. Extensive pre- and postgraduate teaching experience in physiology, pharmacology, toxicology and diabetology. Since 2013 clinical associate professor responsible for lectures, teaching and examination at University of Copenhagen course in clinical pharmacology (30 hours annually).

Summary of Own Research

Ongoing since 2008, I have been an active researcher in topics relating to clinical metabolism and pharmacology. My metabolic research has contributed significantly to understanding the action of endogenous hormones in diabetes and postprandial metabolism, particularly glucose and bone homeostasis and appetite regulation in humans. I am are currently exploring interventions to avoid hypoglycemia in patients with diabetes. My research has among other things led to a patent (WO2016034186A1) that is currently investigated as treatment against obesity and other metabolic disorders.
Since 2013 I have described various aspects and challenges with polypharmacy and how to deal with this by revising medication lists (Medication reviews). In 2017, I obtained funding to and initiated the Polypharmacy Outpatient Clinic at Bispebjerg and Frederiksberg Hospital. This clinic is now responsible for reviewing medications in complex patients with multiple diseases and pharmacological treatments and have shown great results with regards to improvements in pharmacotherapy and health-related quality of life (results awaiting publication).

Research outputs

Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in Beta Cell Function in Patients with Type 2 Diabetes

Stensen, S., Gasbjerg, L. S., Rosenkilde, M. M., Vilsbøll, T., Holst, J. J., Hartmann, B., Christensen, M. B. & Knop, F. K., 7 Jul 2022, (E-pub ahead of print) In: Diabetes.

Effects of a comprehensive medication review intervention on health-related quality of life and other clinical outcomes in geriatric outpatients with polypharmacy: A pragmatic randomized clinical trial

Kornholt, J., Feizi, S. T., Hansen, A. S., Laursen, J. T., Reuther, L. Ø., Petersen, T. S., Pressel, E. & Christensen, M. B., Jul 2022, In: British Journal of Clinical Pharmacology. 88, 7, p. 3360-3369 10 p.

Short-term mortality following tramadol poisonings in Denmark

Sørensen, A. M. S., Petersen, J., Christensen, M. B., Schelde, A. B., Andersen, J. T., Jimenez Solem, E. & Petersen, T. S., Jul 2022, In: Basic & clinical pharmacology & toxicology. 131, 1, p. 83-92 10 p.

Acute concomitant glucose-dependent insulinotropic polypeptide receptor antagonism during glucagon-like peptide 1 receptor agonism does not affect appetite, resting energy expenditure or food intake in patients with type 2 diabetes and overweight/obesity

Stensen, S., Krogh, L. L., Sparre-Ulrich, A. H., Dela, F., Hartmann, B., Vilsbøll, T., Holst, J. J., Rosenkilde, M. M., Christensen, M. B., Gasbjerg, L. S. & Knop, F. K., Sep 2022, In: Diabetes, Obesity and Metabolism. 24, 9, p. 1882-1887 6 p.

Drug use in patients with short bowel syndrome and intestinal failure

Vorre, M. M., Johansson, K. S., Fuglsang, K. A., Horwitz, H., Solem, E. J., Jeppesen, P. B. & Christensen, M. B., 28 Apr 2022, In: Danish Medical Journal. 69, 5

Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0-6 years

Gade, C., Bøgevig, S., Daoud, A., Mathiesen, P. R., Christensen, M. B., Peder Dalhoff, K. & Petersen, T. S., Mar 2022, In: Acta paediatrica. 111, 3, p. 667-674 8 p.

VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center

Amos, B., Aurrecoechea, C., Barba, M., Barreto, A., Basenko, E. Y., Bażant, W., Belnap, R., Blevins, A. S., Böhme, U., Brestelli, J., Brunk, B. P., Caddick, M., Callan, D., Campbell, L., Christensen, M. B., Christophides, G. K., Crouch, K., Davis, K., DeBarry, J., Doherty, R. & 46 others, Duan, Y., Dunn, M., Falke, D., Fisher, S., Flicek, P., Fox, B., Gajria, B., Giraldo-Calderón, G. I., Harb, O. S., Harper, E., Hertz-Fowler, C., Hickman, M. J., Howington, C., Hu, S., Humphrey, J., Iodice, J., Jones, A., Judkins, J., Kelly, S. A., Kissinger, J. C., Kwon, D. K., Lamoureux, K., Lawson, D., Li, W., Lies, K., Lodha, D., Long, J., MacCallum, R. M., Maslen, G., McDowell, M. A., Nabrzyski, J., Roos, D. S., Rund, S. S. C., Schulman, S. W., Shanmugasundram, A., Sitnik, V., Spruill, D., Starns, D., Stoeckert, C. J., Tomko, S. S., Wang, H., Warrenfeltz, S., Wieck, R., Wilkinson, P. A., Xu, L. & Zheng, J., 7 Jan 2022, In: Nucleic Acids Research. 50, D1, p. D898-D911

Glucagon Clearance is Preserved in Type 2 Diabetes

Grøndahl, M. F. G., Lund, A., Bagger, J. I., Petersen, T. S., Wewer Albrechtsen, N. J., Holst, J. J., Vilsbøll, T., Christensen, M. B. & Knop, F. K., Jan 2022, In: Diabetes. 71, 1, p. 73-82 10 p.

Glucose-dependent insulinotropic polypeptide induces lipolysis during stable basal insulin substitution and hyperglycaemia in men with type 1 diabetes: a randomized, double-blind, placebo-controlled, crossover clinical trial

Heimburger, S. M., Nielsen, C. N., Calanna, S., Holst, J. J., Vilsbøll, T., Knop, F. K. & Christensen, M. B., Jan 2022, In: Diabetes, Obesity and Metabolism. 24, 1, p. 142-147 6 p.

Acute changes in plasma glucose increases left ventricular systolic function in insulin-treated patients with type 2 diabetes and controls

Andersen, A., Jørgensen, P. G., Bagger, J. I., Baldassarre, M. P. A., Christensen, M. B., Pedersen-Bjergaard, U., Lindhardt, T. B., Gislason, G., Knop, F. K. & Vilsbøll, T., 2022, In: Diabetes, Obesity and Metabolism. 24, 6, p. 1123-1131 9 p.

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

Kim, A., Knudsen, J. G., Madara, J. C., Benrick, A., Hill, T. G., Abdul Kadir, L., Kellard, J. A., Mellander, L., Miranda, C., Lin, H., James, T., Suba, K., Spigelman, A. F., Wu, Y., MacDonald, P. E., Wernstedt Asterholm, I., Magnussen, T., Christensen, M., Vilsbøll, T., Salem, V. & 4 others, Knop, F. K., Rorsman, P., Lowell, B. B. & Briant, L. J., 17 Nov 2021, In: eLife. 10, e72919.

Exendin(9-39)NH2 - recommendations for clinical use based on a systematic literature review

Gasbjerg, L. S., Bari, E. J., Christensen, M. B. & Knop, F. K., Nov 2021, In: Diabetes, Obesity and Metabolism. 23, 11, p. 2419-2436 18 p.

The effect of 6-day subcutaneous glucose-dependent insulinotropic polypeptide infusion on time in glycaemic range in patients with type 1 diabetes: a randomised, double-blind, placebo-controlled crossover trial

Heimbürger, S. M. N., Hoe, B., Nielsen, C. N., Bergmann, N. C., Hartmann, B., Holst, J. J., Vilsbøll, T., Dejgaard, T. F., Christensen, M. B. & Knop, F. K., Nov 2021, In: Diabetologia. 64, 11, p. 2425-2431 7 p.

MECHANISMS IN ENDOCRINOLOGY: The physiology of neuronostatin

Andersen, M. R., Suppli, M. P., Bagger, J. I., Christensen, M. B., Yosten, G. L. C., Knop, F. K. & Lund, A., 1 Sep 2021, In: European Journal of Endocrinology. 185, 4, p. R93-R101

Causes of discrepancies between medications listed in the national electronic prescribing system and patients' actual use of medications

Bülow, C., Noergaard, J. D. S. V., Faerch, K. U., Pontoppidan, C., Unkerskov, J., Johansson, K. S., Kornholt, J. & Christensen, M. B., Sep 2021, In: Basic and Clinical Pharmacology and Toxicology. 129, 3, p. 221-231 11 p.

Pancreatic polypeptide: A potential biomarker of glucose-dependent insulinotropic polypeptide receptor activation in vivo

Veedfald, S., Bergmann, N. C., Vilsbøll, T., Christensen, M. B., Holst, J. J. & Knop, F. K., Aug 2021, In: Diabetic Medicine. 38, 8, p. e14592 e14592.

Acute hypoglycemia and risk of cardiac arrhythmias in insulin-treated type 2 diabetes and controls

Andersen, A., Bagger, J. I., Baldassarre, M. P., Christensen, M. B., Abelin, K. U., Faber, J., Pedersen-Bjerregaard, U., Holst, J. J., Lindhardt, T. B., Gislason, G. H., Knop, F. K. & Vilsbøll, T., 21 Jul 2021, In: European Journal of Endocrinology. 185, 2, p. 343-353 11 p.

Emerging glucagon-like peptide 1 receptor agonists for the treatment of obesity

Jepsen, M. M. & Christensen, M. B., 3 Jul 2021, In: Expert Opinion on Emerging Drugs. 26, 3, p. 231-243 13 p.

Low-dose aspirin for primary and secondary prevention of cardiovascular events in Denmark 1998-2018

Christensen, M. B., Jimenez-Solem, E., Ernst, M. T., Schmidt, M., Pottegård, A. & Grove, E. L., 30 Jun 2021, In: Scientific Reports. 11, 1, p. 13603 1 p.

Effects of endogenous GIP in patients with type 2 diabetes

Stensen, S., Gasbjerg, L. S., Krogh, L. L., Skov-Jeppesen, K., Sparre-Ulrich, A. H., Jensen, M. H., Dela, F., Hartmann, B., Vilsbøll, T., Holst, J. J., Rosenkilde, M. M., Christensen, M. B. & Knop, F. K., 21 May 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45 13 p.

Medication errors in residential facilities based on Danish Poison Information Center inquiries

Bakkedal, C., Eriksen, K. R., Hansen, N. B., Petersen, T. S., Dalhoff, K. P., Bøgevig, S., Rizing, M. P. & Christensen, M. B., 28 Apr 2021, In: Danish Medical Journal. 68, 5, p. A11200800

An overview of obesity mechanisms in humans: Endocrine regulation of food intake, eating behaviour and common determinants of body weight

Theilade, S., Christensen, M. B., Vilsbøll, T. & Knop, F. K., Feb 2021, In: Diabetes, Obesity and Metabolism. 23, S1, p. 17-35 19 p.

Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment

Hagemann, C. A., Zhang, C., Hansen, H. H., Jorsal, T., Rigbolt, K. T. G., Madsen, M. R., Bergmann, N. C., Heimbürger, S. M. N., Falkenhahn, M., Theis, S., Breitschopf, K., Holm, S., Hedegaard, M. A., Christensen, M. B., Vilsbøll, T., Holst, B., Vrang, N., Jelsing, J. & Knop, F. K., Feb 2021, In: The Journal of clinical endocrinology and metabolism. 106, 2, p. e966-e981

Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist GIP(3-30)NH2 on GIP actions in humans

Gasbjerg, L. S., Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, M. B., Hartmann, B., Holst, J. J., Rosenkilde, M. M. & Knop, F. K., Jan 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74 7 p.

Anvendt klinisk farmakologi

Dalhoff, K. P. (ed.), Andersen, S. E. (ed.), Hellebek, A. H., Jürgens, G., Christensen, H. R., Holst, H., Andersen, J. T., Enghusen-Poulsen, H., Christensen, M. B., Horwitz, H., Harboe, K. M., Reuther, L. Ø., Christiansen, M. L. S., Nørgaard, M., Petersen, T. S. & Skov, K., 2021, 1 ed. FADL's Forlag. 260 p.

GIP peptide analogues: US Patent 10,968,266, 2021

Christensen, M. B., 2021, Patent No. 10968266

Systemisk toksicitet ved lokalanalgetika

Johansson, K. S., Høgberg, L. C. G., Christensen, M. B., Petersen, T. S., Dalhoff, K. & Bøgevig, S., 14 Dec 2020, In: Ugeskrift for Laeger. 182, 51

Glycemic control and use of glucose-lowering medications in hospital-admitted type 2 diabetes patients over 80 years

Gotfredsen, D. R., Vinther, S., Petersen, T. S., Cortes, R., Jensen, T. B., Jimenez-Solem, E. & Christensen, M. B., 1 Dec 2020, In: Scientific Reports. 10, 1, p. 4095 4095.

GIP(3-30)NH2 - a tool for the study of GIP physiology

Lynggaard, M. B., Gasbjerg, L. S., Christensen, M. B. & Knop, F. K., Dec 2020, In: Current Opinion in Pharmacology. 55, p. 31-40 10 p.

Multidisciplinær håndtering af svær jernforgiftning som følge af suicidalforsøg

Petersen, S. M., Boysen, T., Svane, M. S. & Christensen, M. B., 9 Nov 2020, In: Ugeskrift for Laeger. 182, 46

A poison information centre can provide important assessment and guidance regarding medication errors in nursing homes: A prospective cohort study

Vinther, S., Bøgevig, S., Eriksen, K. R., Hansen, N. B., Petersen, T. S., Dalhoff, K. P. & Christensen, M. B., 4 Nov 2020, (E-pub ahead of print) In: Basic & clinical pharmacology & toxicology.

High-Dose Glucagon Has Hemodynamic Effects Regardless of Cardiac Beta-Adrenoceptor Blockade: A Randomized Clinical Trial

Petersen, K. M., Bøgevig, S., Riis, T., Andersson, N. W., Dalhoff, K. P., Holst, J. J., Knop, F. K., Faber, J., Petersen, T. S. & Christensen, M. B., 3 Nov 2020, In: Journal of the American Heart Association. 9, 21, p. e016828

The role of endogenous GIP and GLP-1 in postprandial bone homeostasis

Helsted, M. M., Gasbjerg, L. S., Lanng, A. R., Bergmann, N. C., Stensen, S., Hartmann, B., Christensen, M. B., Holst, J. J., Vilsbøll, T., Rosenkilde, M. M. & Knop, F. K., Nov 2020, In: Bone. 140, p. 115553 115553.

What is on the horizon for type 2 diabetes pharmacotherapy? - An overview of the antidiabetic drug development pipeline

Johansson, K. S., Sonne, D. P., Knop, F. K. & Christensen, M. B., Nov 2020, In: Expert Opinion on Drug Discovery. 15, 11, p. 1253-1265 13 p.

Medication-related experiences of patients with polypharmacy: a systematic review of qualitative studies

Eriksen, C. U., Kyriakidis, S., Christensen, L. D., Jacobsen, R., Laursen, J., Christensen, M. B. & Frølich, A., 6 Sep 2020, In: BMJ Open. 10, 9, p. e036158

Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent

Jensen, M. E., Galli, A., Thomsen, M., Jensen, K. L., Thomsen, G. K., Klausen, M. K., Vilsbøll, T., Christensen, M. B., Holst, J. J., Owens, A., Robertson, S., Daws, L., Zanella, D., Gether, U., Knudsen, G. M. & Fink-Jensen, A., 1 Sep 2020, In: Neurochemistry International. 138, p. 104772 104772.

Glucose-dependent Insulinotropic Polypeptide (GIP) reduces bone resorption in patients with type 2 diabetes

Christensen, M. B., Lund, A. B., Jørgensen, N. R., Holst, J. J., Vilsbøll, T. & Knop, F. K., 1 Sep 2020, In: Journal of the Endocrine Society. 4, 9, p. bvaa097 bvaa097.

Cardiovascular effects of high-dose glucagon: a randomised clinical trial

Petersen, K. M., Bogevig, S., Riis, T., Andersson, N. A. W., Dalhoff, K. P., Holst, J. J., Knop, F. K., Faber, J., Petersen, T. S. & Christensen, M. B., Sep 2020, p. S231-S231.

Identification of a gut-derived LEAP2 fragment as a novel insulin secretagogue

Hagemann, C. A., Zhang, C., Jorsal, T., Rigbolt, K. T., Falkenhahn, M., Theis, S., Christensen, M., Vilsboll, T., Vrang, N., Jelsing, J. & Knop, F. K., Sep 2020, p. S70-S70.

Sex and age differences among tramadol users in three Nordic countries

Schelde, A. B., Sørensen, A. M. S., Hindsø, M., Christensen, M. B., Jimenez-Solem, E. & Eriksson, R., 1 Jul 2020, In: Danish Medical Journal. 67, 7, p. 1-12 12 p., A06190336.

Prevalence of polypharmacy in Denmark

Kornholt, J. & Christensen, M. B., 1 Jun 2020, In: Danish Medical Journal. 67, 6

Clinical pharmacology of imeglimin for the treatment of type 2 diabetes

Johansson, K. S., Brønden, A., Knop, F. K. & Christensen, M. B., 23 May 2020, In: Expert Opinion on Pharmacotherapy. 21, 8, p. 871-882 12 p.

Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists

Gasbjerg, L. S., Bergmann, N. C., Stensen, S., Christensen, M. B., Rosenkilde, M. M., Holst, J. J., Nauck, M. & Knop, F. K., Mar 2020, In: Peptides. 125, 170183.

GIP and the gut-bone axis - physiological, pathophysiological and potential therapeutic implications

Stensen, S., Gasbjerg, L. S., Helsted, M. M., Hartmann, B., Christensen, M. B. & Knop, F. K., Mar 2020, In: Peptides. 170197.

GIP's involvement in the pathophysiology of type 2 diabetes

Christensen, M. B., Gasbjerg, L. S., Heimbürger, S. M., Stensen, S., Vilsbøll, T. & Knop, F. K., Mar 2020, In: Peptides. 125, 170178.

Glucose-dependent insulinotropic polypeptide (GIP) and cardiovascular disease

Heimbürger, S. M., Bergmann, N. C., Augustin, R., Gasbjerg, L. S., Christensen, M. B. & Knop, F. K., Mar 2020, In: Peptides. 125, 170174.

No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes

Bergmann, N. C., Gasbjerg, L. S., Heimbürger, S. M., Krogh, L. S. L., Dela, F., Hartmann, B., Holst, J. J., Jessen, L., Christensen, M. B., Vilsbøll, T., Lund, A. & Knop, F. K., Mar 2020, In: Diabetes Care. 43, 3, p. 588-596 9 p., dc190578.

GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2

Gasbjerg, L. S., Hartmann, B., Christensen, M. B., Lanng, A. R., Vilsbøll, T., Jørgensen, N. R., Holst, J. J., Rosenkilde, M. M. & Knop, F. K., 1 Jan 2020, In: Bone. 130, 115079.

Analgesics use and withdrawal in people with dementia - a register-based Danish study and a systematic review

Sørensen, A. M. S., Tarp, S., Johannsen, P., Lolk, A., Bandak, E., Pedersen, H., Saxtrup, N., Kallehauge, H., Solem, E. J. & Christensen, M. B., Dec 2019, In: Danish Medical Journal. 66, 12, p. A5578

The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion - A Review

Mathiesen, D. S., Bagger, J. I., Bergmann, N. C., Lund, A., Christensen, M. B., Vilsbøll, T. & Knop, F. K., 22 Aug 2019, In: International Journal of Molecular Sciences. 20, 17, 4092.

Separate and Combined Effects of GIP and GLP-1 Infusions on Bone Metabolism in Overweight Men without Diabetes

Bergmann, N. C., Lund, A., Gasbjerg, L. S., Jørgensen, N. R., Jessen, L., Hartmann, B., Holst, J. J., Christensen, M. B., Vilsbøll, T. & Knop, F. K., Jul 2019, In: The Journal of clinical endocrinology and metabolism. 104, 7, p. 2953-2960 8 p.

Separate and Combined Gluco-Metabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 in Healthy Individuals

Gasbjerg, L. S., Helsted, M. M., Hartmann, B., Jensen, M. H., Gabe, M. B. N., Sparre-Ulrich, A. H., Veedfald, S., Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, M. B., Vilsbøll, T., Holst, J. J., Rosenkilde, M. M. & Knop, F. K., May 2019, In: Diabetes. 68, 5, p. 906-917 12 p.

Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study

Bergmann, N. C., Lund, A., Gasbjerg, L. S., Meessen, E. C. E., Andersen, M. M., Bergmann, S., Hartmann, B., Holst, J. J., Jessen, L., Christensen, M. B., Vilsbøll, T. & Knop, F. K., 1 Apr 2019, In: Diabetologia. 62, 4, p. 665-675 11 p.

Long term treatment with stimulant laxatives - clinical evidence for effectiveness and safety?

Noergaard, M., Traerup Andersen, J., Jimenez-Solem, E. & Bring Christensen, M., 31 Jan 2019, In: Scandinavian Journal of Gastroenterology. 54, 1, p. 27-34 8 p.

Two-bag intravenous N-acetylcysteine, antihistamine pretreatment and high plasma paracetamol levels are associated with a lower incidence of anaphylactoid reactions to N-acetylcysteine

Daoud, A., Dalhoff, K. P., Christensen, M. B., Bøgevig, S. & Petersen, T. S., 2019, In: Clinical toxicology (Philadelphia, Pa.). p. 698-704 7 p.

Ventrikelaspiration er meget sjældent indiceret ved forgiftninger

Bøgevig, S., Christensen, M. B., Petersen, J. A., Dalhoff, K. P., Petersen, T. S., Palmqvist, D. F. & Groth Høgberg, L. C., 3 Dec 2018, In: Ugeskrift for Laeger. 180, 49

Polypharmacy and medication deprescribing: A survey among multimorbid older adults in Denmark

Schiøtz, M. L., Frølich, A., Jensen, A. K., Reuther, L., Perrild, H., Petersen, T. S., Kornholt, J. & Christensen, M. B., Dec 2018, In: Pharmacology Research & Perspectives. 6, 6, p. e00431

Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects

Demant, M., Bagger, J. I., Suppli, M. P., Lund, A., Gyldenløve, M., Hansen, K. B., Hare, K. J., Christensen, M., Sonne, D. P., Holst, J. J., Vilsbøll, T. & Knop, F. K., 28 Nov 2018, In: Metabolic Syndrome and Related Disorders. 16, 10, p. 530-536 6 p.

Effects of high-dose, intravenous lipid emulsion on laboratory tests in humans: a randomized, placebo-controlled, double-blind, clinical crossover trial

Petersen, K. M., Jørgensen, N. R., Bøgevig, S., Petersen, T. S., Jensen, T. B., Dalhoff, K. P. & Christensen, M. B., 27 Nov 2018, In: Clinical Chemistry and Laboratory Medicine. 56, 12, p. 2047-2057 11 p.

Outcomes following calcium channel blocker exposures reported to a poison information center

Christensen, M. B., Petersen, K. M., Bøgevig, S., Al-Gibouri, S., Jimenez-Solem, E., Dalhoff, K. P., Petersen, T. S. & Andersen, J. T., 27 Nov 2018, In: BMC pharmacology & toxicology. 19, 1, p. 78

Hemodynamic effects of intravenous, high-dose lipid emulsion with and without metoprolol infusion in healthy volunteers: a randomized clinical trial

Meidahl Petersen, K., Bøgevig, S., Petersen, T. S., Jensen, T. B., Dalhoff, K. P., Henriksen, T., Poulsen, H. E. & Christensen, M. B., 9 Nov 2018, (E-pub ahead of print) In: Clinical Pharmacology and Therapeutics.

Mono- and co-activation of the GIP and GLP-1 receptors inhibits bone resorption

Bergmann, N., Lund, A., Heimbürger, S. M., Gasbjerg, L. S., Jørgensen, N. R., Jessen, L., Hartmann, B., Holst, J. J., Christensen, M., Vilsbøll, T. & Knop, F. K., 1 Oct 2018, In: Diabetologia. 61, suppl 1, p. S348-S348 1 p., 717.

Postprandial effects of individual and combined GIP and GLP-1 receptor antagonism in healthy subjects

Gasbjerg, L. S., Helsted, M. M., Sparre-Ulrich, A. H., Lanng, A. R., Stensen, S., Jakobsen, M. H., Hartmann, B., Christensen, M., Holst, J. J., Vilsbøll, T., Rosenkilde, M. M. & Knop, F. K., 1 Oct 2018, In: Diabetologia. 61, suppl 1, p. S246-S246 1 p., 503.

The role of the incretins in the postprandial bone remodelling

Helsted, M. M., Gasbjerg, L. S., Lanng, A. R., Stensen, S., Hartmann, B., Christensen, M., Holst, J. J., Vilsbøll, T., Rosenkilde, M. & Knop, F. K., 1 Oct 2018, In: Diabetologia. 61, Suppl 1, p. S221-S221 1 p., 449.

Preclinical discovery and development of colesevelam for the treatment of type 2 diabetes

Nerild, H. H., Christensen, M. B., Knop, F. K. & Brønden, A., Oct 2018, In: Expert Opinion on Drug Discovery. 13, 12, p. 1161-1167 8 p.

General Practitioners' Barriers Toward Medication Reviews in Polymedicated Multimorbid Patients: How can a Focus on the Pharmacotherapy in an Outpatient Clinic Support GPs?

Laursen, J., Kornholt, J., Betzer, C., Petersen, T. S. & Christensen, M. B., 25 Sep 2018, In: Health services research and managerial epidemiology. 5, p. 2333392818792169

Cardiovascular effects of antidiabetic drugs

Sørensen, A. M. & Christensen, M. B., Sep 2018, In: Drugs of Today. 54, 9, p. 547-559 13 p.

Effect of a medicines management model on medication-related readmissions in older patients admitted to a medical acute admission unit-A randomized controlled trial

Graabaek, T., Hedegaard, U., Christensen, M. B., Clemmensen, M. H., Knudsen, T. & Aagaard, L., 7 Aug 2018, (E-pub ahead of print) In: Journal of Evaluation in Clinical Practice.

A Systematic Review on Insulin Overdose Cases: Clinical Course, Complications and Novel Treatment Options

Johansen, N. J. & Christensen, M. B., Jun 2018, In: Basic & clinical pharmacology & toxicology. 122, 6, p. 650-659 9 p.

Hemodynamic Effects of Glucagon - A Literature Review

Meidahl Petersen, K., Bøgevig, S., Holst, J. J., Knop, F. K. & Christensen, M. B., 1 May 2018, In: The Journal of clinical endocrinology and metabolism. 103, 5, p. 1804-1812 8 p.

GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study

Gasbjerg, L. S., Christensen, M. B., Hartmann, B., Lanng, A. R., Sparre-Ulrich, A. H., Gabe, M. B. N., Dela, F., Vilsbøll, T., Holst, J. J., Rosenkilde, M. M. & Knop, F. K., Feb 2018, In: Diabetologia. 61, 2, p. 413-423 10 p.

Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents

Gasbjerg, L. S., Gabe, M. B. N., Hartmann, B., Christensen, M. B., Knop, F. K., Holst, J. J. & Rosenkilde, M. M., Feb 2018, In: Peptides. 100, p. 173-181 9 p.

Important Aspects of Pharmacist-led Medication Reviews in an Acute Medical Ward

Bülow, C., Faerch, K. U., Armandi, H., Jensen, B. N., Sonne, J., Christensen, H. R. & Christensen, M. B., Feb 2018, In: Basic & clinical pharmacology & toxicology. 122, 2, p. 253-261 9 p.

Overdoses with Aripiprazole: Signs, Symptoms and Outcome in 239 Exposures Reported to the Danish Poison Information Centre

Christensen, A. P., Boegevig, S., Christensen, M. B., Petersen, K. M., Dalhoff, K. P. & Petersen, T. S., Feb 2018, In: Basic & clinical pharmacology & toxicology. 122, 2, p. 293-298 6 p.

Glucose-Dependent Insulinotropic Polypeptide (GIP) Inhibits Bone Resorption independently of Insulin and Glycemia

Christensen, M. B., Lund, A., Calanna, S., Jørgensen, N. R., Holst, J. J., Vilsbøll, T. & Knop, F. K., 2018, In: The Journal of clinical endocrinology and metabolism. 103, 1, p. 288-294 7 p.

Quality of care for people with multimorbidity - a case series

Schiøtz, M. L., Høst, D., Christensen, M. B., Domínguez, H., Hamid, Y., Almind, M., Sørensen, K. L., Saxild, T., Holm, R. H. & Frølich, A., 18 Nov 2017, In: BMC Health Services Research. 17, 1, p. 745

An adverse drug event manager facilitates spontaneous reporting of adverse drug reactions

Vinther, S., Klarskov, P., Borgeskov, H., Darsø, P., Christophersen, A. K., Borck, B., Christensen, C., Hansen, M. V., Halladin, N. M. L., Christensen, M. B., Harboe, K. M., Lund, M. & Jimenez-Solem, E., Jan 2017, In: Danish Medical Bulletin (Online). 64, 1, p. A5315

Non-Insulin Parenteral Therapies

Vilsbøll, T., Christensen, M. & Knop, F. K., 2017, Textbook of Diabetes. p. 453

Hypoglycaemia when adding sulphonylurea to metformin: a systematic review and network meta-analysis

Andersen, S. E. & Christensen, M., Nov 2016, In: British Journal of Clinical Pharmacology. 82, 5, p. 1291-1302 12 p.

Higher Endogenous Glucose Production during OGTT vs Isoglycemic Intravenous Glucose Infusion

Lund, A., Bagger, J. I., Christensen, M., Grøndahl, M., van Hall, G., Holst, J. J., Vilsbøll, T. & Knop, F. K., 17 Aug 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 11, p. 4377-4384

Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585-597

Lund, A., Bagger, J. I., Wewer Albrechtsen, N. J., Christensen, M., Grøndahl, M., Hartmann, B., Mathiesen, E. R., Hansen, C. P., Storkholm, J. H., van Hall, G., Rehfeld, J. F., Hornburg, D., Meissner, F., Mann, M., Larsen, S., Holst, J. J., Vilsbøll, T. & Knop, F. K., Jun 2016

Cholecystokinin-Induced Gallbladder Emptying and Metformin Elicit Additive Glucagon-Like Peptide-1 Responses

Sonne, D. P., Rohde, U., Christensen, M., Hansen, M., Brønden, A., Toräng, S., Rehfeld, J. F., Holst, J. J., Vilsbøll, T. & Knop, F. K., May 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 5, p. 2076-83 8 p.

Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans

Christensen, M. B., Apr 2016, In: Danish Medical Bulletin (Online). 63, 4, 19 p., B5230.

Searching for the physiological role of glucose-dependent insulinotropic polypeptide

Holst, J. J., Windeløv, J. A., Boer, G. A., Pedersen, J., Svendsen, B., Christensen, M., Torekov, S., Asmar, M., Hartmann, B. & Nissen, A., Apr 2016, In: Journal of Diabetes Investigation. 7 Suppl 1, p. 8-12 5 p.

Medication review in hospitalised patients to reduce morbidity and mortality

Christensen, M. & Lundh, A., 20 Feb 2016, In: Cochrane Database of Systematic Reviews. 2, p. CD008986 84 p.

Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors

Sparre-Ulrich, A. H., Hansen, L. S., Svendsen, B., Christensen, M., Knop, F. K., Hartmann, B., Holst, J. J. & Rosenkilde, M. M., Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 27-38 12 p.

Benefits and Harms of Sodium-Glucose Co-Transporter 2 Inhibitors in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Storgaard, H., Gluud, L. L., Bennett, C., Grøndahl, M. F., Christensen, M. B., Knop, F. K. & Vilsbøll, T., 2016, In: P L o S One. 11, 11, p. e0166125

Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes

Christensen, M., Sparre-Ulrich, A. H., Hartmann, B., Grevstad, U., Rosenkilde, M. M., Holst, J. J., Vilsbøll, T. & Knop, F. K., Nov 2015, In: International journal of obesity (2005). 39, 11, p. 1651-4 4 p.

Laktoseholdige lægemidler kan som hovedregel indtages af personer med laktoseintolerans

Vinther, S., Rumessen, J. J. & Christensen, M., 9 Mar 2015, In: Ugeskrift for Laeger. 177, V11140608, p. 2-5 4 p.

Albiglutide for treating type 2 diabetes: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy

Brønden, A., Naver, S. V., Knop, F. K. & Christensen, M., 2015, In: Expert Opinion on Drug Metabolism & Toxicology. 11, 9, p. 1493-503 11 p.

Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes

Christensen, M., Calanna, S., Sparre-Ulrich, A. H., Kristensen, P. L., Rosenkilde, M. M., Faber, J., Purrello, F., van Hall, G., Holst, J. J., Vilsbøll, T. & Knop, F. K., 2015, In: Diabetes. 64, 1, p. 72-78

Glucagon and type 2 diabetes: the return of the alpha cell

Lund, A., Bagger, J. I., Christensen, M., Knop, F. K. & Vilsbøll, T., Dec 2014, In: Current Diabetes Reports. 14, 12, p. 555

Glucose-dependent Insulinotropic Polypeptide Inhibits Bone Resorption in Humans

Nissen, A. G. B., Christensen, M., Knop, F. K., Vilsbøll, T., Holst, J. J. & Hartmann, B., 21 Aug 2014, In: The Journal of clinical endocrinology and metabolism. p. jc20142547

The design and discovery of lixisenatide for the treatment of type 2 diabetes mellitus

Christensen, M., Miossec, P., Larsen, B. D., Werner, U. & Knop, F. K., 14 Aug 2014, In: Expert Opinion on Drug Discovery. p. 1-29 29 p.

Elimination and Degradation of Glucagon-like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide in Patients with End-Stage Renal Disease

Idorn, T., Knop, F. K., Jørgensen, M. B., Christensen, M., Holst, J. J., Hornum, M. & Feldt-Rasmussen, B., Jul 2014, In: The Journal of clinical endocrinology and metabolism. 99, 7, p. 2457-66 10 p.

Adverse effects associated with high-dose olanzapine therapy in patients admitted to inpatient psychiatric care

Petersen, A. B., Andersen, S. E., Christensen, M. & Larsen, H. L., Jan 2014, In: Clinical toxicology (Philadelphia, Pa.). 52, 1, p. 39-43 5 p.

Ensembl Genomes 2013: scaling up access to genome-wide data

Kersey, P. J., Allen, J. E., Christensen, M., Davis, P., Falin, L. J., Grabmueller, C., Hughes, D. S. T., Humphrey, J., Kerhornou, A., Khobova, J., Langridge, N., McDowall, M. D., Maheswari, U., Maslen, G., Nuhn, M., Ong, C. K., Paulini, M., Pedro, H., Toneva, I., Tuli, M. A. & 13 others, Walts, B., Williams, G., Wilson, D., Youens-Clark, K., Monaco, M. K., Stein, J., Wei, X., Ware, D., Bolser, D. M., Howe, K. L., Kulesha, E., Lawson, D. & Staines, D. M., Jan 2014, In: Nucleic Acids Research. 42, Database issue, p. D546-52

The effects of sodium-glucose co-transporter 2 inhibitors in patients with type 2 diabetes: protocol for a systematic review with meta-analysis of randomised trials

Storgaard, H., Gluud, L. L., Christensen, M., Knop, F. K. & Vilsbøll, T., 2014, In: B M J Open. 4, 8, p. e005378

Medication review in hospitalised patients to reduce morbidity and mortality

Christensen, M. & Lundh, A., 2013, In: Cochrane Database of Systematic Reviews. 2, p. CD008986

International or national publication of case reports

Lundh, A., Christensen, M. & Jørgensen, A. W., 2011, In: Danish Medical Bulletin. 58, 2, p. A4242

Malokoplaki i colon behandlet med sulfamethizol og trimetoprim

Christensen, M., Knuhtsen, S. & Knudsen, E., 2011, In: Ugeskrift for Laeger. 173, 7, p. 509-10 2 p.

Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes

Christensen, M., Knop, F. K., Vilsbøll, T., Aaboe, K., Holst, J. J., Madsbad, S. & Krarup, T., 9 Aug 2010, In: Regulatory Peptides. 163, 1-3, p. 96-101 6 p.

The hypothalamo-pituitary-adrenal axis in major affective disorder: a review

Christensen, M. V. & Kessing, L. V., 2001, In: Nordic Journal of Psychiatry. 55, 5, p. 359-63 5 p.

ID: 33192852