Research
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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Expertises

Co-founder and world-leading within Neurostereology, which is a method that allows for precise estimations of total neuron and cell numbers based on mathematical principles of random sampling

Main research areas

Through the 1990ies an onward the main research was focused on the application of Neurostereology to human brains in order to describe structural changes caused by gender, age and disease. Diseases investigated included among other, schizophrenia, AIDS, Alzheimer's Disease, chronic alcoholism, ALS and Parkinson's Disease. The main focus has been to obtain data for the human brain using methods superior to those previously available. Secondly, to be able to explain functional deficits from anatomical changes. 

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Current research

Recently we have been setting up a molecular unit at the research laboratory to unite the techniques of stereology with the methods of molecular biology. The present and future aims are to apply stereology and molecular biology to animal models of brain disorders and to perform translational studies on animal models and postmortem human brains with special focus on neurodegenerative diseases such as Multiple System Atrophy and Parkinson´s disease. It is our goal to combine broad expertise with human brain processing, all-round histological stainings and neuroanatomical resolution with molecular biology, immunohistochemistry and in situ-hybridization in order to get a deeper understanding of the causes behind these diseases.

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