Research
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Bispebjerg Hospital - a part of Copenhagen University Hospital
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Expertises

Mass spectrometry; chromatography; sample preparation; bioanalysis.

Main research areas

It is generally accepted that oxidation of guanine in DNA and RNA can readily occur during sample handling and preparation. It has also been described, that often the methods used for the quantification of oxidative stress markers of DNA and RNA lacks specificity. As a consequence of lack of specificity and artificial oxidation the levels of oxidative stress markers reported in different biological matrices (e.g. nucleic acids from tissue and DNA and RNA break down products in cerebrospinal fluid) varies by several orders of magnitude.

My research is on developing quantitative methods based on liquid chromatography combined with tandem mass spectrometry for a specific, sensitive and accurate determination of DNA and RNA oxidation products in various biological matrices. In addition I am trying to find and characterize new DNA and RNA oxidation products.

My research is the basis for our laboratory’s research in areas like optimizing the treatment of type 2 diabetes and the search for a better understanding of hemochromatosis, Alzheimer's disease and heart failure.

Current research

Development of a quantitative method based on liquid chromatography combined with tandem mass spectrometry for a specific, sensitive and accurate determination of DNA and RNA oxidation products in cerebrospinal fluid.

Characterisation of a new nucleic acid oxidation product found in humans and rodents.

Potential conflicts of interest

None

ID: 30991764