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The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test

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Dam Mygind, N, Axelsson, A, Ruwald, MH, Dalsgaard, M, Steffensen, R, Iversen, K, Johansen, JS & Kastrup, J 2016, 'The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test', Cardiovascular Endocrinology, bind 5, nr. 1, s. 21-27. https://doi.org/10.1097/XCE.0000000000000073

APA

Dam Mygind, N., Axelsson, A., Ruwald, M. H., Dalsgaard, M., Steffensen, R., Iversen, K., Johansen, J. S., & Kastrup, J. (2016). The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test. Cardiovascular Endocrinology, 5(1), 21-27. https://doi.org/10.1097/XCE.0000000000000073

CBE

Dam Mygind N, Axelsson A, Ruwald MH, Dalsgaard M, Steffensen R, Iversen K, Johansen JS, Kastrup J. 2016. The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test. Cardiovascular Endocrinology. 5(1):21-27. https://doi.org/10.1097/XCE.0000000000000073

MLA

Vancouver

Author

Dam Mygind, Naja ; Axelsson, Anna ; Ruwald, Martin H ; Dalsgaard, Morten ; Steffensen, Rolf ; Iversen, Kasper ; Johansen, Julia S ; Kastrup, Jens. / The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test. I: Cardiovascular Endocrinology. 2016 ; Bind 5, Nr. 1. s. 21-27.

Bibtex

@article{b8de33ea3c464d7d960148713b9fac90,
title = "The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test",
abstract = "BACKGROUND: Serum YKL-40 is an inflammatory biomarker associated with disease activity and mortality in diseases characterized by inflammation such as coronary artery disease (CAD). Exercise has a positive effect on CAD, possibly mediated by a decreased inflammatory activity. This study aimed to compare serial measurements of serum YKL-40 before and after exercise in patients with stable CAD versus controls.MATERIALS AND METHODS: Eleven patients with stable CAD verified by coronary angiography (>70% stenosis) and 11 patients with a computer tomography angiography with no stenosis or calcification (calcium score=0) (controls) performed a standard clinical maximal exercise test. Serum YKL-40 was measured before exercise, immediately after exercise, and every hour for 6 h.RESULTS: Cardiovascular risk factors were more prevalent among the CAD patients compared with the controls. CAD patients had higher serum concentration of YKL-40 at baseline compared with controls, median (interquartile range) 94 (52-151) versus 57 (45-79) μg/l. Serum YKL-40 decreased stepwise after exercise, with a median decrease of 16 (13-39) μg/l for the CAD patients and 13 (10-22) μg/l for the controls from baseline to the lowest value. Thereafter, values increased again toward baseline level. Time after exercise was a significant factor for decrease in serum YKL-40 (P<0.0001), but no difference in YKL-40 decrease over time could be demonstrated between the groups (P=0.12).CONCLUSION: Serum YKL-40 is elevated in patients with documented CAD compared with controls, and it decreases stepwise after exercise in both groups, indicating an anti-inflammatory effect of exercise independent of the presence of coronary atherosclerosis.",
keywords = "Journal Article",
author = "{Dam Mygind}, Naja and Anna Axelsson and Ruwald, {Martin H} and Morten Dalsgaard and Rolf Steffensen and Kasper Iversen and Johansen, {Julia S} and Jens Kastrup",
year = "2016",
doi = "10.1097/XCE.0000000000000073",
language = "English",
volume = "5",
pages = "21--27",
journal = "Cardiovascular Endocrinology",
issn = "2162-6898",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test

AU - Dam Mygind, Naja

AU - Axelsson, Anna

AU - Ruwald, Martin H

AU - Dalsgaard, Morten

AU - Steffensen, Rolf

AU - Iversen, Kasper

AU - Johansen, Julia S

AU - Kastrup, Jens

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Serum YKL-40 is an inflammatory biomarker associated with disease activity and mortality in diseases characterized by inflammation such as coronary artery disease (CAD). Exercise has a positive effect on CAD, possibly mediated by a decreased inflammatory activity. This study aimed to compare serial measurements of serum YKL-40 before and after exercise in patients with stable CAD versus controls.MATERIALS AND METHODS: Eleven patients with stable CAD verified by coronary angiography (>70% stenosis) and 11 patients with a computer tomography angiography with no stenosis or calcification (calcium score=0) (controls) performed a standard clinical maximal exercise test. Serum YKL-40 was measured before exercise, immediately after exercise, and every hour for 6 h.RESULTS: Cardiovascular risk factors were more prevalent among the CAD patients compared with the controls. CAD patients had higher serum concentration of YKL-40 at baseline compared with controls, median (interquartile range) 94 (52-151) versus 57 (45-79) μg/l. Serum YKL-40 decreased stepwise after exercise, with a median decrease of 16 (13-39) μg/l for the CAD patients and 13 (10-22) μg/l for the controls from baseline to the lowest value. Thereafter, values increased again toward baseline level. Time after exercise was a significant factor for decrease in serum YKL-40 (P<0.0001), but no difference in YKL-40 decrease over time could be demonstrated between the groups (P=0.12).CONCLUSION: Serum YKL-40 is elevated in patients with documented CAD compared with controls, and it decreases stepwise after exercise in both groups, indicating an anti-inflammatory effect of exercise independent of the presence of coronary atherosclerosis.

AB - BACKGROUND: Serum YKL-40 is an inflammatory biomarker associated with disease activity and mortality in diseases characterized by inflammation such as coronary artery disease (CAD). Exercise has a positive effect on CAD, possibly mediated by a decreased inflammatory activity. This study aimed to compare serial measurements of serum YKL-40 before and after exercise in patients with stable CAD versus controls.MATERIALS AND METHODS: Eleven patients with stable CAD verified by coronary angiography (>70% stenosis) and 11 patients with a computer tomography angiography with no stenosis or calcification (calcium score=0) (controls) performed a standard clinical maximal exercise test. Serum YKL-40 was measured before exercise, immediately after exercise, and every hour for 6 h.RESULTS: Cardiovascular risk factors were more prevalent among the CAD patients compared with the controls. CAD patients had higher serum concentration of YKL-40 at baseline compared with controls, median (interquartile range) 94 (52-151) versus 57 (45-79) μg/l. Serum YKL-40 decreased stepwise after exercise, with a median decrease of 16 (13-39) μg/l for the CAD patients and 13 (10-22) μg/l for the controls from baseline to the lowest value. Thereafter, values increased again toward baseline level. Time after exercise was a significant factor for decrease in serum YKL-40 (P<0.0001), but no difference in YKL-40 decrease over time could be demonstrated between the groups (P=0.12).CONCLUSION: Serum YKL-40 is elevated in patients with documented CAD compared with controls, and it decreases stepwise after exercise in both groups, indicating an anti-inflammatory effect of exercise independent of the presence of coronary atherosclerosis.

KW - Journal Article

U2 - 10.1097/XCE.0000000000000073

DO - 10.1097/XCE.0000000000000073

M3 - Journal article

C2 - 28392973

VL - 5

SP - 21

EP - 27

JO - Cardiovascular Endocrinology

JF - Cardiovascular Endocrinology

SN - 2162-6898

IS - 1

ER -

ID: 50245778