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The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population: the copenhagen city heart study

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Skaarup, Kristoffer Grundtvig ; Lassen, Mats Christian Højbjerg ; Marott, Jacob Louis ; Biering-Sørensen, Sofie R ; Jørgensen, Peter Godsk ; Appleyard, Merete ; Berning, Jens ; Høst, Nis ; Jensen, Gorm ; Schnohr, Peter ; Søgaard, Peter ; Gislason, Gunnar ; Møgelvang, Rasmus ; Biering-Sørensen, Tor. / The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population : the copenhagen city heart study. I: The international journal of cardiovascular imaging. 2020 ; Bind 36, Nr. 10. s. 1907-1916.

Bibtex

@article{4a1b23928fb74eeb8047555147130b11,
title = "The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population: the copenhagen city heart study",
abstract = "Global longitudinal strain (GLS) declines throughout adult-life as the LV remodels and adapts. Information on the impact of cardiac risk factors such as male sex, obesity, smoking status, hypertension, hypercholesterolemia, and diabetes on GLS. over time has not yet been investigated. The present prospective longitudinal study included 689 participants of the 4th and 5th Copenhagen City Heart Study who had GLS measured at both timepoints. Mean age was 51 years and 45% were male. All participants underwent two echocardiographic examinations median 10.4 (IQR: 10.2, 10.9) years apart. Average decline in GLS during follow-up was -0.7%. High age, male sex, high body mass index, and mean arterial blood pressure (MAP) proved to be significantly associated with an accelerated decline in GLS. In a multivariable regression model including all the investigated cardiovascular risk factors, age (stand. β-coef. = -0.10, P = 0.005), male sex (stand. β-coef. = -0.16, P < 0.001), and MAP (stand. β-coef. = -0.07, P = 0.009) were independent predictors of an accelerated decline in GLS during a 10-year period. Finally, the investigated risk factors had different regional impact after the same multivariable adjustments. Male sex had a significant impact on changes in longitudinal strain at the apical, mid-wall and basal segments, meanwhile MAP and age only accelerated changes in the mid-wall and basal longitudinal strain. In the general population age, male sex, and MAP are independent predictors of an accelerated decline in GLS over a 10-year period. Furthermore, MAP, male sex and age had different regional impact.",
keywords = "Adaptation, Physiological, Adult, Aged, Cardiovascular Diseases/diagnostic imaging, Denmark/epidemiology, Echocardiography, Doppler, Female, Humans, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, Ventricular Function, Left, Ventricular Remodeling, Echocardiography, General population, Global longitudinal strain, Risk factors",
author = "Skaarup, {Kristoffer Grundtvig} and Lassen, {Mats Christian H{\o}jbjerg} and Marott, {Jacob Louis} and Biering-S{\o}rensen, {Sofie R} and J{\o}rgensen, {Peter Godsk} and Merete Appleyard and Jens Berning and Nis H{\o}st and Gorm Jensen and Peter Schnohr and Peter S{\o}gaard and Gunnar Gislason and Rasmus M{\o}gelvang and Tor Biering-S{\o}rensen",
year = "2020",
month = oct,
doi = "10.1007/s10554-020-01906-5",
language = "English",
volume = "36",
pages = "1907--1916",
journal = "International Journal of Cardiovascular Imaging",
issn = "1569-5794",
publisher = "Springer Netherlands",
number = "10",

}

RIS

TY - JOUR

T1 - The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population

T2 - the copenhagen city heart study

AU - Skaarup, Kristoffer Grundtvig

AU - Lassen, Mats Christian Højbjerg

AU - Marott, Jacob Louis

AU - Biering-Sørensen, Sofie R

AU - Jørgensen, Peter Godsk

AU - Appleyard, Merete

AU - Berning, Jens

AU - Høst, Nis

AU - Jensen, Gorm

AU - Schnohr, Peter

AU - Søgaard, Peter

AU - Gislason, Gunnar

AU - Møgelvang, Rasmus

AU - Biering-Sørensen, Tor

PY - 2020/10

Y1 - 2020/10

N2 - Global longitudinal strain (GLS) declines throughout adult-life as the LV remodels and adapts. Information on the impact of cardiac risk factors such as male sex, obesity, smoking status, hypertension, hypercholesterolemia, and diabetes on GLS. over time has not yet been investigated. The present prospective longitudinal study included 689 participants of the 4th and 5th Copenhagen City Heart Study who had GLS measured at both timepoints. Mean age was 51 years and 45% were male. All participants underwent two echocardiographic examinations median 10.4 (IQR: 10.2, 10.9) years apart. Average decline in GLS during follow-up was -0.7%. High age, male sex, high body mass index, and mean arterial blood pressure (MAP) proved to be significantly associated with an accelerated decline in GLS. In a multivariable regression model including all the investigated cardiovascular risk factors, age (stand. β-coef. = -0.10, P = 0.005), male sex (stand. β-coef. = -0.16, P < 0.001), and MAP (stand. β-coef. = -0.07, P = 0.009) were independent predictors of an accelerated decline in GLS during a 10-year period. Finally, the investigated risk factors had different regional impact after the same multivariable adjustments. Male sex had a significant impact on changes in longitudinal strain at the apical, mid-wall and basal segments, meanwhile MAP and age only accelerated changes in the mid-wall and basal longitudinal strain. In the general population age, male sex, and MAP are independent predictors of an accelerated decline in GLS over a 10-year period. Furthermore, MAP, male sex and age had different regional impact.

AB - Global longitudinal strain (GLS) declines throughout adult-life as the LV remodels and adapts. Information on the impact of cardiac risk factors such as male sex, obesity, smoking status, hypertension, hypercholesterolemia, and diabetes on GLS. over time has not yet been investigated. The present prospective longitudinal study included 689 participants of the 4th and 5th Copenhagen City Heart Study who had GLS measured at both timepoints. Mean age was 51 years and 45% were male. All participants underwent two echocardiographic examinations median 10.4 (IQR: 10.2, 10.9) years apart. Average decline in GLS during follow-up was -0.7%. High age, male sex, high body mass index, and mean arterial blood pressure (MAP) proved to be significantly associated with an accelerated decline in GLS. In a multivariable regression model including all the investigated cardiovascular risk factors, age (stand. β-coef. = -0.10, P = 0.005), male sex (stand. β-coef. = -0.16, P < 0.001), and MAP (stand. β-coef. = -0.07, P = 0.009) were independent predictors of an accelerated decline in GLS during a 10-year period. Finally, the investigated risk factors had different regional impact after the same multivariable adjustments. Male sex had a significant impact on changes in longitudinal strain at the apical, mid-wall and basal segments, meanwhile MAP and age only accelerated changes in the mid-wall and basal longitudinal strain. In the general population age, male sex, and MAP are independent predictors of an accelerated decline in GLS over a 10-year period. Furthermore, MAP, male sex and age had different regional impact.

KW - Adaptation, Physiological

KW - Adult

KW - Aged

KW - Cardiovascular Diseases/diagnostic imaging

KW - Denmark/epidemiology

KW - Echocardiography, Doppler

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Time Factors

KW - Ventricular Function, Left

KW - Ventricular Remodeling

KW - Echocardiography

KW - General population

KW - Global longitudinal strain

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=85086096330&partnerID=8YFLogxK

U2 - 10.1007/s10554-020-01906-5

DO - 10.1007/s10554-020-01906-5

M3 - Journal article

C2 - 32507994

VL - 36

SP - 1907

EP - 1916

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 10

ER -

ID: 61265868