Forskning
Udskriv Udskriv
Switch language
Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

The association between depressive mood and ischemic heart disease: a twin study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Use of register and survey-based measures of anxiety in a population based Danish cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Number of Traumatic brain injuries and temporal associations with depression: A register-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Time course of symptoms in posttraumatic stress disorder with delayed expression: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Severe mental illness is associated with increased mortality and severe course of COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Familial risk and heritability of depression by age at first diagnosis in Danish twins

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Social inequality in tooth loss: separate and joint effects of household income and dental visits

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association of fatal myocardial infarction with past level of physical activity: a pooled analysis of cohort studies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Use of register and survey-based measures of anxiety in a population based Danish cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Body mass index and height in young adult men in relation to subsequent risk of mood disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Number of Traumatic brain injuries and temporal associations with depression: A register-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Individuals with mood disorders have increased risk of cardiovascular disease. The aims of this study were to evaluate if the risk of cardiovascular disease in individuals with mood disorder could be explained by shared genetic and early environmental factors.

METHODS: We included 6714 Danish middle and old aged twins from two large population-based studies. Cox proportional hazards regression was used to perform individual-level and intra-pair analyses of the association between self-reported depression symptomatology scores and register-based diagnoses of ischemic heart disease.

RESULTS: Higher depression symptomatology scores (both total, affective, and somatic) were associated with higher incidence of ischemic heart disease after multivariable adjustment in individual-level analyses. In intra-pair analyses, this association was similar but with slightly larger confidence intervals. There was no interaction with gender and no major differences between mono- or dizygotic twins. Within twin pairs, the twin scoring highest on depressive symptoms developed ischemic heart disease more often or earlier than the lower scoring twin. A sensitivity analysis including a 2-year time lag of depression symptomatology to limit the risk of reverse causality showed similar results.

CONCLUSION: Genetic factors and early life environment do not seem to explain the association between depressive mood and ischemic heart disease.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind140
Udgave nummer3
Sider (fra-til)265-274
Antal sider10
ISSN0001-690X
DOI
StatusUdgivet - sep. 2019

Bibliografisk note

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ID: 57783000