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Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

Ten-year clinical outcome of patients treated with a drug-eluting stent in the proximal left anterior descending artery segment compared with patients stented in other non-left main coronary segments

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Predictors of 10-Year Stent-Related Adverse Outcomes after Coronary Drug-Eluting Stent Implantation: The Importance of Stent Size

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Diagnosis and Treatment of Genetic HFE-Hemochromatosis: The Danish Aspect

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  3. Genetic HFE-haemochromatosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. 10-Year Clinical Outcome After Randomization to Treatment by Sirolimus- or Paclitaxel-Eluting Coronary Stents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Lars Kjøller-Hansen
  • Niels Bligaard
  • Henning Kelbæk
  • Evald Høj Christiansen
  • Leif Thuesen
  • Peter R Hansen
  • Thomas Engstrøm
  • Anders Junker
  • Ulrik Abildgaard
  • Jens Flensted Lassen
  • Jan S Jensen
  • Jørgen L Jeppesen
  • Anders M Galløe
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AIMS: The aim of the study was to determine whether patients treated with drug-eluting stents in the proximal left anterior descending artery (LAD) carried a different long-term prognosis from patients treated in other coronary artery segments.

METHODS AND RESULTS: Ten-year clinical outcome expressed as all-cause mortality and major adverse cardiac events (MACE: cardiac death, acute myocardial infarction, or target vessel revascularisation) was determined for 1,479 patients with a single non-left main coronary stenosis treated with a first-generation drug-eluting stent in the SORT OUT II trial. The outcome of patients treated with stents in the proximal LAD (n=365) was compared with that of patients treated in a non-proximal LAD segment (n=1,114). Follow-up was 99.3% complete. All-cause mortality was 24.9% in the proximal LAD group vs. 26.3% in the non-proximal LAD group (p=0.60). MACE occurred less frequently in the proximal LAD group, 24.6% vs. 31.0% with a hazard ratio of 0.77 (95% confidence interval [CI]: 0.61-0.97, p=0.024). After multivariate analysis which included baseline characteristics that were unevenly distributed between the groups, the hazard ratio for MACE was 0.82 (95% CI: 0.65-1.03, p=0.09).

CONCLUSIONS: Patients treated with a drug-eluting stent in the proximal LAD have similar, if not better, long-term clinical outcome compared with patients stented in other coronary artery segments.

OriginalsprogEngelsk
TidsskriftEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Vol/bind14
Udgave nummer7
Sider (fra-til)764-771
Antal sider8
ISSN1774-024X
DOI
StatusUdgivet - 20 sep. 2018

ID: 55409555