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Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Barcella, CA, Mohr, G, Kragholm, K, Christensen, D, Gerds, TA, Polcwiartek, C, Wissenberg, M, Bang, C, Folke, F, Torp-Pedersen, C, Kessing, LV, Gislason, GH & Bach Søndergaard, K 2021, 'Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia', Heart (British Cardiac Society), bind 107, nr. 19, heartjnl-2020-318078, s. 1544-1551. https://doi.org/10.1136/heartjnl-2020-318078

APA

Barcella, C. A., Mohr, G., Kragholm, K., Christensen, D., Gerds, T. A., Polcwiartek, C., Wissenberg, M., Bang, C., Folke, F., Torp-Pedersen, C., Kessing, L. V., Gislason, G. H., & Bach Søndergaard, K. (2021). Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia. Heart (British Cardiac Society), 107(19), 1544-1551. [heartjnl-2020-318078]. https://doi.org/10.1136/heartjnl-2020-318078

CBE

Barcella CA, Mohr G, Kragholm K, Christensen D, Gerds TA, Polcwiartek C, Wissenberg M, Bang C, Folke F, Torp-Pedersen C, Kessing LV, Gislason GH, Bach Søndergaard K. 2021. Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia. Heart (British Cardiac Society). 107(19):1544-1551. https://doi.org/10.1136/heartjnl-2020-318078

MLA

Vancouver

Barcella CA, Mohr G, Kragholm K, Christensen D, Gerds TA, Polcwiartek C o.a. Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia. Heart (British Cardiac Society). 2021 sep;107(19):1544-1551. heartjnl-2020-318078. https://doi.org/10.1136/heartjnl-2020-318078

Author

Barcella, Carlo Alberto ; Mohr, Grimur ; Kragholm, Kristian ; Christensen, Daniel ; Gerds, Thomas A ; Polcwiartek, Christoffer ; Wissenberg, Mads ; Bang, Casper ; Folke, Fredrik ; Torp-Pedersen, Christian ; Kessing, Lars Vedel ; Gislason, Gunnar Hilmar ; Bach Søndergaard, Kathrine. / Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia. I: Heart (British Cardiac Society). 2021 ; Bind 107, Nr. 19. s. 1544-1551.

Bibtex

@article{72af8ee185064b609a145eaa89a85f40,
title = "Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia",
abstract = "OBJECTIVE: Patients with bipolar disorder and schizophrenia are at high cardiovascular risk; yet, the risk of out-of-hospital cardiac arrest (OHCA) compared with the general population remains scarcely investigated.METHODS: We conducted a nested case-control study using Cox regression to assess the association of bipolar disorder and schizophrenia with the HRs of OHCA of presumed cardiac cause (2001-2015). Reported are the HRs with 95% CIs overall and in subgroups defined by established cardiac disease, cardiovascular risk factors and psychotropic drugs.RESULTS: We included 35 017 OHCA cases and 175 085 age-matched and sex-matched controls (median age 72 years and 66.9% male). Patients with bipolar disorder or schizophrenia had overall higher rates of OHCA compared with the general population: HR 2.74 (95% CI 2.41 to 3.13) and 4.49 (95% CI 4.00 to 5.10), respectively. The association persisted in patients with both cardiac disease and cardiovascular risk factors at baseline (bipolar disorder HR 2.14 (95% CI 1.72 to 2.66), schizophrenia 2.84 (95% CI 2.20 to 3.67)) and among patients without known risk factors (bipolar disorder HR 2.14 (95% CI 1.09 to 4.21), schizophrenia HR 5.16 (95% CI 3.17 to 8.39)). The results were confirmed in subanalyses only including OHCAs presenting with shockable rhythm or receiving an autopsy. Antipsychotics-but not antidepressants, lithium or antiepileptics (the last two only tested in bipolar disorder)-increased OHCA hazard compared with no use in both disorders.CONCLUSIONS: Patients with bipolar disorder or schizophrenia have a higher rate of OHCA compared with the general population. Cardiac disease, cardiovascular risk factors and antipsychotics represent important underlying mechanisms.",
keywords = "cardiac arrest, cardiac risk factors and prevention, epidemiology, ventricular arrhythmia ablation procedures, ventricular tachycardia",
author = "Barcella, {Carlo Alberto} and Grimur Mohr and Kristian Kragholm and Daniel Christensen and Gerds, {Thomas A} and Christoffer Polcwiartek and Mads Wissenberg and Casper Bang and Fredrik Folke and Christian Torp-Pedersen and Kessing, {Lars Vedel} and Gislason, {Gunnar Hilmar} and {Bach S{\o}ndergaard}, Kathrine",
note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = sep,
doi = "10.1136/heartjnl-2020-318078",
language = "English",
volume = "107",
pages = "1544--1551",
journal = "Heart",
issn = "1355-6037",
publisher = "B M J Group",
number = "19",

}

RIS

TY - JOUR

T1 - Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia

AU - Barcella, Carlo Alberto

AU - Mohr, Grimur

AU - Kragholm, Kristian

AU - Christensen, Daniel

AU - Gerds, Thomas A

AU - Polcwiartek, Christoffer

AU - Wissenberg, Mads

AU - Bang, Casper

AU - Folke, Fredrik

AU - Torp-Pedersen, Christian

AU - Kessing, Lars Vedel

AU - Gislason, Gunnar Hilmar

AU - Bach Søndergaard, Kathrine

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9

Y1 - 2021/9

N2 - OBJECTIVE: Patients with bipolar disorder and schizophrenia are at high cardiovascular risk; yet, the risk of out-of-hospital cardiac arrest (OHCA) compared with the general population remains scarcely investigated.METHODS: We conducted a nested case-control study using Cox regression to assess the association of bipolar disorder and schizophrenia with the HRs of OHCA of presumed cardiac cause (2001-2015). Reported are the HRs with 95% CIs overall and in subgroups defined by established cardiac disease, cardiovascular risk factors and psychotropic drugs.RESULTS: We included 35 017 OHCA cases and 175 085 age-matched and sex-matched controls (median age 72 years and 66.9% male). Patients with bipolar disorder or schizophrenia had overall higher rates of OHCA compared with the general population: HR 2.74 (95% CI 2.41 to 3.13) and 4.49 (95% CI 4.00 to 5.10), respectively. The association persisted in patients with both cardiac disease and cardiovascular risk factors at baseline (bipolar disorder HR 2.14 (95% CI 1.72 to 2.66), schizophrenia 2.84 (95% CI 2.20 to 3.67)) and among patients without known risk factors (bipolar disorder HR 2.14 (95% CI 1.09 to 4.21), schizophrenia HR 5.16 (95% CI 3.17 to 8.39)). The results were confirmed in subanalyses only including OHCAs presenting with shockable rhythm or receiving an autopsy. Antipsychotics-but not antidepressants, lithium or antiepileptics (the last two only tested in bipolar disorder)-increased OHCA hazard compared with no use in both disorders.CONCLUSIONS: Patients with bipolar disorder or schizophrenia have a higher rate of OHCA compared with the general population. Cardiac disease, cardiovascular risk factors and antipsychotics represent important underlying mechanisms.

AB - OBJECTIVE: Patients with bipolar disorder and schizophrenia are at high cardiovascular risk; yet, the risk of out-of-hospital cardiac arrest (OHCA) compared with the general population remains scarcely investigated.METHODS: We conducted a nested case-control study using Cox regression to assess the association of bipolar disorder and schizophrenia with the HRs of OHCA of presumed cardiac cause (2001-2015). Reported are the HRs with 95% CIs overall and in subgroups defined by established cardiac disease, cardiovascular risk factors and psychotropic drugs.RESULTS: We included 35 017 OHCA cases and 175 085 age-matched and sex-matched controls (median age 72 years and 66.9% male). Patients with bipolar disorder or schizophrenia had overall higher rates of OHCA compared with the general population: HR 2.74 (95% CI 2.41 to 3.13) and 4.49 (95% CI 4.00 to 5.10), respectively. The association persisted in patients with both cardiac disease and cardiovascular risk factors at baseline (bipolar disorder HR 2.14 (95% CI 1.72 to 2.66), schizophrenia 2.84 (95% CI 2.20 to 3.67)) and among patients without known risk factors (bipolar disorder HR 2.14 (95% CI 1.09 to 4.21), schizophrenia HR 5.16 (95% CI 3.17 to 8.39)). The results were confirmed in subanalyses only including OHCAs presenting with shockable rhythm or receiving an autopsy. Antipsychotics-but not antidepressants, lithium or antiepileptics (the last two only tested in bipolar disorder)-increased OHCA hazard compared with no use in both disorders.CONCLUSIONS: Patients with bipolar disorder or schizophrenia have a higher rate of OHCA compared with the general population. Cardiac disease, cardiovascular risk factors and antipsychotics represent important underlying mechanisms.

KW - cardiac arrest

KW - cardiac risk factors and prevention

KW - epidemiology

KW - ventricular arrhythmia ablation procedures

KW - ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=85099643053&partnerID=8YFLogxK

U2 - 10.1136/heartjnl-2020-318078

DO - 10.1136/heartjnl-2020-318078

M3 - Journal article

C2 - 33452118

VL - 107

SP - 1544

EP - 1551

JO - Heart

JF - Heart

SN - 1355-6037

IS - 19

M1 - heartjnl-2020-318078

ER -

ID: 61787086