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Predictors of 10-Year Stent-Related Adverse Outcomes after Coronary Drug-Eluting Stent Implantation: The Importance of Stent Size

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Harvard

Kjøller-Hansen, L, Kelbæk, H, Christiansen, EH, Hansen, PR, Engstrøm, T, Junker, A, Bligaard, N, Jeppesen, JL & Galløe, AM 2021, 'Predictors of 10-Year Stent-Related Adverse Outcomes after Coronary Drug-Eluting Stent Implantation: The Importance of Stent Size', Cardiology, bind 146, nr. 6, s. 705-712. https://doi.org/10.1159/000517614

APA

Kjøller-Hansen, L., Kelbæk, H., Christiansen, E. H., Hansen, P. R., Engstrøm, T., Junker, A., Bligaard, N., Jeppesen, J. L., & Galløe, A. M. (2021). Predictors of 10-Year Stent-Related Adverse Outcomes after Coronary Drug-Eluting Stent Implantation: The Importance of Stent Size. Cardiology, 146(6), 705-712. https://doi.org/10.1159/000517614

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MLA

Vancouver

Author

Kjøller-Hansen, Lars ; Kelbæk, Henning ; Christiansen, Evald Høj ; Hansen, Peter Riis ; Engstrøm, Thomas ; Junker, Anders ; Bligaard, Niels ; Jeppesen, Jørgen Lykke ; Galløe, Anders Michael. / Predictors of 10-Year Stent-Related Adverse Outcomes after Coronary Drug-Eluting Stent Implantation : The Importance of Stent Size. I: Cardiology. 2021 ; Bind 146, Nr. 6. s. 705-712.

Bibtex

@article{01eba804d77743b5b421cdfa84ff3e81,
title = "Predictors of 10-Year Stent-Related Adverse Outcomes after Coronary Drug-Eluting Stent Implantation: The Importance of Stent Size",
abstract = "INTRODUCTION: The predictors of stent treatment failure and their importance 10 years after treatment with drug-eluting stents (DESs) have not been reported in detail.METHODS: Data were retrieved from the SORT-OUT II database encompassing 2,849 non-left main coronary lesions in 2,073 unselected all-comer patients treated with first-generation DES and followed clinically for 10 years. Stent treatment failure (STF) was defined as definite or probable stent thrombosis, target lesion revascularization (TLR), or >70% restenosis left untreated. Target lesion failure (TLF) was defined as cardiac death, target vessel myocardial infarction, or TLR. Characteristics predicting higher hazard ratios (HRs) were identified by the multivariate Cox regression analysis.RESULTS: A stent diameter ≤2.5 versus ≥3.5 mm had STF 23.3 versus 11.8% and TLF 27.9 versus 18.8%. Stent length <20 versus >40 mm had STF 13.0 versus 29.0% and TLF 18.7 versus 34.6%. In multivariate analysis, decreasing stent diameter (HR: 1.24 [3.0 mm] to 2.12 [2.25 mm], reference ≥3.5 mm) and increasing stent length (HR: 1.15 [20-30 mm] to 2.07 [>40 mm], reference <20 mm) predicted STF together with diabetes (HR: 1.31), previous revascularization (HR: 1.31), restenotic (HR: 2.25), bifurcation (HR: 1.45), and chronically occluded lesions (HR: 1.54). A predictive score (PS) was calculated for each lesion from the HRs for the predictors present. The 10-year rates of STF were 10% in lesions with a PS ≤ 1.5 and 37% in those with PS ≥ 3.5.CONCLUSIONS: Ten-year outcomes show large variations depending on the stent size and a few patient and lesion characteristics. The calculation of a PS from these unambiguous variables may be used to improve the risk estimate in individual lesions and patients.",
keywords = "Coronary artery disease, PCI, PTCA, Predictors, Restenosis, PTCA/PCI",
author = "Lars Kj{\o}ller-Hansen and Henning Kelb{\ae}k and Christiansen, {Evald H{\o}j} and Hansen, {Peter Riis} and Thomas Engstr{\o}m and Anders Junker and Niels Bligaard and Jeppesen, {J{\o}rgen Lykke} and Gall{\o}e, {Anders Michael}",
note = "{\textcopyright} 2021 S. Karger AG, Basel.",
year = "2021",
doi = "10.1159/000517614",
language = "English",
volume = "146",
pages = "705--712",
journal = "HeartDrug",
issn = "0008-6312",
publisher = "S./Karger AG",
number = "6",

}

RIS

TY - JOUR

T1 - Predictors of 10-Year Stent-Related Adverse Outcomes after Coronary Drug-Eluting Stent Implantation

T2 - The Importance of Stent Size

AU - Kjøller-Hansen, Lars

AU - Kelbæk, Henning

AU - Christiansen, Evald Høj

AU - Hansen, Peter Riis

AU - Engstrøm, Thomas

AU - Junker, Anders

AU - Bligaard, Niels

AU - Jeppesen, Jørgen Lykke

AU - Galløe, Anders Michael

N1 - © 2021 S. Karger AG, Basel.

PY - 2021

Y1 - 2021

N2 - INTRODUCTION: The predictors of stent treatment failure and their importance 10 years after treatment with drug-eluting stents (DESs) have not been reported in detail.METHODS: Data were retrieved from the SORT-OUT II database encompassing 2,849 non-left main coronary lesions in 2,073 unselected all-comer patients treated with first-generation DES and followed clinically for 10 years. Stent treatment failure (STF) was defined as definite or probable stent thrombosis, target lesion revascularization (TLR), or >70% restenosis left untreated. Target lesion failure (TLF) was defined as cardiac death, target vessel myocardial infarction, or TLR. Characteristics predicting higher hazard ratios (HRs) were identified by the multivariate Cox regression analysis.RESULTS: A stent diameter ≤2.5 versus ≥3.5 mm had STF 23.3 versus 11.8% and TLF 27.9 versus 18.8%. Stent length <20 versus >40 mm had STF 13.0 versus 29.0% and TLF 18.7 versus 34.6%. In multivariate analysis, decreasing stent diameter (HR: 1.24 [3.0 mm] to 2.12 [2.25 mm], reference ≥3.5 mm) and increasing stent length (HR: 1.15 [20-30 mm] to 2.07 [>40 mm], reference <20 mm) predicted STF together with diabetes (HR: 1.31), previous revascularization (HR: 1.31), restenotic (HR: 2.25), bifurcation (HR: 1.45), and chronically occluded lesions (HR: 1.54). A predictive score (PS) was calculated for each lesion from the HRs for the predictors present. The 10-year rates of STF were 10% in lesions with a PS ≤ 1.5 and 37% in those with PS ≥ 3.5.CONCLUSIONS: Ten-year outcomes show large variations depending on the stent size and a few patient and lesion characteristics. The calculation of a PS from these unambiguous variables may be used to improve the risk estimate in individual lesions and patients.

AB - INTRODUCTION: The predictors of stent treatment failure and their importance 10 years after treatment with drug-eluting stents (DESs) have not been reported in detail.METHODS: Data were retrieved from the SORT-OUT II database encompassing 2,849 non-left main coronary lesions in 2,073 unselected all-comer patients treated with first-generation DES and followed clinically for 10 years. Stent treatment failure (STF) was defined as definite or probable stent thrombosis, target lesion revascularization (TLR), or >70% restenosis left untreated. Target lesion failure (TLF) was defined as cardiac death, target vessel myocardial infarction, or TLR. Characteristics predicting higher hazard ratios (HRs) were identified by the multivariate Cox regression analysis.RESULTS: A stent diameter ≤2.5 versus ≥3.5 mm had STF 23.3 versus 11.8% and TLF 27.9 versus 18.8%. Stent length <20 versus >40 mm had STF 13.0 versus 29.0% and TLF 18.7 versus 34.6%. In multivariate analysis, decreasing stent diameter (HR: 1.24 [3.0 mm] to 2.12 [2.25 mm], reference ≥3.5 mm) and increasing stent length (HR: 1.15 [20-30 mm] to 2.07 [>40 mm], reference <20 mm) predicted STF together with diabetes (HR: 1.31), previous revascularization (HR: 1.31), restenotic (HR: 2.25), bifurcation (HR: 1.45), and chronically occluded lesions (HR: 1.54). A predictive score (PS) was calculated for each lesion from the HRs for the predictors present. The 10-year rates of STF were 10% in lesions with a PS ≤ 1.5 and 37% in those with PS ≥ 3.5.CONCLUSIONS: Ten-year outcomes show large variations depending on the stent size and a few patient and lesion characteristics. The calculation of a PS from these unambiguous variables may be used to improve the risk estimate in individual lesions and patients.

KW - Coronary artery disease

KW - PCI

KW - PTCA

KW - Predictors

KW - Restenosis

KW - PTCA/PCI

UR - http://www.scopus.com/inward/record.url?scp=85112348484&partnerID=8YFLogxK

U2 - 10.1159/000517614

DO - 10.1159/000517614

M3 - Journal article

C2 - 34343998

VL - 146

SP - 705

EP - 712

JO - HeartDrug

JF - HeartDrug

SN - 0008-6312

IS - 6

ER -

ID: 66975267