Forskning
Udskriv Udskriv
Switch language
Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Neonatal vitamin D status and myopia in young adult men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Visual acuity and amblyopia prevalence in 11- to 12-year-old Danish children from the Copenhagen Child Cohort 2000

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Exposure to topical chloramphenicol during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Influence of educational level on test and treatment for incident hypothyroidism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Explaining deep neural networks for knowledge discovery in electrocardiogram analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Predictive Importance of Blood Pressure Characteristics With Increasing Age in Healthy Men and Women: The MORGAM Project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. På vej mod en sundere og bedre behandlet befolkning?

    Publikation: Bidrag til tidsskriftKommentar/debatFormidling

Vis graf over relationer

PURPOSE: To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.

METHODS: Cross-sectional study of 848 subjects aged 30-60 years from the Inter99 Eye Study. Daily intake of vitamins and minerals was estimated from a 198-item food frequency questionnaire. Digital fundus photographs were recorded in red-free illumination and graded for macular drusen >63 μm and numerous (>20) small hard macular drusen as a mean of both eyes.

RESULTS: Higher intake of vitamin A increased the risk of having macular drusen >63 μm with odds ratio = 1.82 (CI95 1.02-3.24, p = 0.042) comparing participants in the highest quartile of vitamin A intake with participants in the lowest quartile, adjusted for recruitment group, age and sex. There was a significant interaction with CFHY402H (p = 0.038). Among 504 participants with CFHY402H, the relative risk of having macular drusen >63 μm was increased in participants in the highest quartile of vitamin A intake (odds ratio = 2.58; CI95 1.16-5.73, p = 0.020) and in the second highest quartile (odds ratio = 3.27; CI95 1.50-7.13, p = 0.0029) compared with the lowest quartile. Further adjusting for total fat intake, energy intake, plasma cholesterol, body mass index (BMI), smoking, alcohol intake, education and physical activity strengthened the association.

CONCLUSIONS: In this cross-sectional study, a higher intake of vitamin A increased the risk of macular drusen >63 μm in subjects with CFHY402H. The study supports that vitamin A may be a risk factor for early AMD.

OriginalsprogEngelsk
TidsskriftActa Ophthalmologica
Vol/bind94
Udgave nummer7
Sider (fra-til)657-662
Antal sider6
ISSN1755-375X
DOI
StatusUdgivet - nov. 2016

ID: 49595459