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Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

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Georg, B, Ghelli, A, Giordano, C, Ross-Cisneros, FN, Sadun, AA, Carelli, V, Hannibal, J & La Morgia, C 2017, 'Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always' Mitochondrion, bind 36, s. 77-84. https://doi.org/10.1016/j.mito.2017.04.003

APA

Georg, B., Ghelli, A., Giordano, C., Ross-Cisneros, F. N., Sadun, A. A., Carelli, V., ... La Morgia, C. (2017). Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always. Mitochondrion, 36, 77-84. https://doi.org/10.1016/j.mito.2017.04.003

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Author

Georg, Birgitte ; Ghelli, Anna ; Giordano, Carla ; Ross-Cisneros, Fred N ; Sadun, Alfredo A ; Carelli, Valerio ; Hannibal, Jens ; La Morgia, Chiara. / Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always. I: Mitochondrion. 2017 ; Bind 36. s. 77-84.

Bibtex

@article{39c3e82f4c4a4643aacd97563e9d3a8e,
title = "Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always",
abstract = "Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs.",
keywords = "Journal Article",
author = "Birgitte Georg and Anna Ghelli and Carla Giordano and Ross-Cisneros, {Fred N} and Sadun, {Alfredo A} and Valerio Carelli and Jens Hannibal and {La Morgia}, Chiara",
note = "Copyright {\circledC} 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.",
year = "2017",
month = "9",
doi = "10.1016/j.mito.2017.04.003",
language = "English",
volume = "36",
pages = "77--84",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

AU - Georg, Birgitte

AU - Ghelli, Anna

AU - Giordano, Carla

AU - Ross-Cisneros, Fred N

AU - Sadun, Alfredo A

AU - Carelli, Valerio

AU - Hannibal, Jens

AU - La Morgia, Chiara

N1 - Copyright © 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

PY - 2017/9

Y1 - 2017/9

N2 - Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs.

AB - Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs.

KW - Journal Article

U2 - 10.1016/j.mito.2017.04.003

DO - 10.1016/j.mito.2017.04.003

M3 - Journal article

VL - 36

SP - 77

EP - 84

JO - Mitochondrion

JF - Mitochondrion

SN - 1567-7249

ER -

ID: 52158414