Forskning
Udskriv Udskriv
Switch language
Bispebjerg Hospital - en del af Københavns Universitetshospital
E-pub ahead of print

Maternal pre-pregnancy overweight and infertility in sons and daughters: a cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Female cigarette smoking and successful fertility treatment: a Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Use of thyroid hormones in relation to pregnancy: a Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Effect of socioeconomic position on patients' outcome after hysterectomy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Validity of self-reported birthweight among middle-aged and elderly women in the Danish Nurse Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Natarbejde og komplikationer i graviditeten

    Publikation: Bidrag til tidsskriftReviewpeer review

  2. Maternal life and work stressors during pregnancy and asthma in offspring

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Occupational exposures and exacerbations of asthma and COPD-A general population study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. How to schedule night shift work in order to reduce health and safety risks

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION: Overweight and obesity in pregnancy is increasing worldwide and may harm the developing fetus including its future reproductive health. We therefore studied the association between maternal overweight and obesity in fetal life and infertility in adulthood. No studies have previously assessed this association.

MATERIAL AND METHODS: We performed a cohort study with 9,232 adult sons and daughters, whose mothers were enrolled in the Danish Healthy Habits for Two cohort during pregnancy in 1984-87. Participants were sons and daughters, followed in the Danish In-Vitro-Fertilization-Register and Danish National Patient Register until February 2018 for diagnoses of infertility.

RESULTS: In total, 1,203 (13 %) sons and daughters were born to mothers with a body mass index (BMI) above 25 kg/m2 , and 871 (9.4 %) participants were identified as being infertile during follow-up. Sons of overweight mothers had slightly increased odds of infertility compared to sons of mothers with normal body weight (BMI: 18.5-24.9 kg/m2 , adjusted odds ratio 1.4 (95 % CI 1.0-1.9). Cubic spline analyses with continuous BMI levels, showed increasing odds with higher levels of BMI, however, for BMI>29 kg/m2 the CIs were too wide to draw conclusions. No association between maternal overweight and infertility was found among daughters (adjusted odds ratio 0.9 (95% CI 0.7-1.2)).

CONCLUSIONS: Sons born to overweight mothers had higher odds of infertility compared to sons of normal weight mothers. No association between maternal overweight and infertility was observed in daughters. Prevention of overweight during pregnancy may be an important tool to preserve fecundity in future generations.

OriginalsprogEngelsk
TidsskriftActa Obstetricia et Gynecologica Scandinavica
ISSN0001-6349
DOI
StatusE-pub ahead of print - 15 nov. 2020

Bibliografisk note

This article is protected by copyright. All rights reserved.

ID: 61373423