Forskning
Udskriv Udskriv
Switch language
Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

Maternal exposure to airborne polychlorinated biphenyls (PCBs) and risk of adverse birth outcomes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Body mass index and height in young adult men in relation to subsequent risk of mood disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Are depressive disorders caused by psychosocial stressors at work? A systematic review with metaanalysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Body mass index and height in relation to type 2 diabetes by levels of intelligence and education in a large cohort of Danish men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Body mass index and risk of infections: a Mendelian randomization study of 101,447 individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Intake of n-3 LCPUFA and trans-fatty acids is unrelated to development in body mass index and body fat among children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Occupational inhalant exposures and longitudinal lung function decline

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Development and cross-cultural validation of the Goal Content for Weight Maintenance Scale (GCWMS)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Human health effects of airborne lower-chlorinated polychlorinated biphenyls (LC-PCBs) are largely unexplored. Since PCBs may cross the placenta, maternal exposure could potentially have negative consequences for fetal development. We aimed to determine if exposure to airborne PCB during pregnancy was associated with adverse birth outcomes. In this cohort study, exposed women had lived in PCB contaminated apartments at least one year during the 3.6 years before conception or the entire first trimester of pregnancy. The women and their children were followed for birth outcomes in Danish health registers. Logistic regression was performed to estimate odds ratios (OR) for changes in secondary sex ratio, preterm birth, major congenital malformations, cryptorchidism, and being born small for gestational age. We performed linear regression to estimate difference in birth weight among children of exposed and unexposed mothers. All models were adjusted for maternal age, educational level, ethnicity, and calendar time. We identified 885 exposed pregnancies and 3327 unexposed pregnancies. Relative to unexposed women, exposed women had OR 0.97 (95% CI 0.82, 1.15) for secondary sex ratio, OR 1.13 (95% CI 0.76, 1.67) for preterm birth, OR 1.28 (95% CI 0.81, 2.01) for having a child with major malformations, OR 1.73 (95% CI 1.01, 2.95) for cryptorchidism and OR 1.23 (95% CI 0.88, 1.72) for giving birth to a child born small for gestational age. The difference in birth weight for children of exposed compared to unexposed women was - 32 g (95% CI-79, 14). We observed an increased risk of cryptorchidism among boys after maternal airborne LC-PCB exposure, but due to the proxy measure of exposure, inability to perform dose-response analyses, and the lack of comparable literature, larger cohort studies with direct measures of exposure are needed to investigate the safety of airborne LC-PCB exposure during pregnancy.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind36
Udgave nummer8
Sider (fra-til)861-872
Antal sider12
ISSN0393-2990
DOI
StatusUdgivet - aug. 2021

Bibliografisk note

© 2021. The Author(s).

ID: 68414136