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Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study

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Harvard

Skaarup, KG, Lassen, MCH, Espersen, C, Lind, JN, Johansen, ND, Sengeløv, M, Alhakak, AS, Nielsen, AB, Ravnkilde, K, Hauser, R, Schöps, LB, Holt, E, Bundgaard, H, Hassager, C, Jabbari, R, Carlsen, J, Kirk, O, Bodtger, U, Lindholm, MG, Wiese, L, Kristiansen, OP, Walsted, ES, Nielsen, OW, Lindegaard, B, Tønder, N, Jeschke, KN, Ulrik, CS, Lamberts, M, Sivapalan, P, Pallisgaard, J, Gislason, G, Iversen, K, Jensen, JUS, Schou, M, Skaarup, SH, Platz, E & Biering-Sørensen, T 2021, 'Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study', Journal of ultrasound, s. 1-11. https://doi.org/10.1007/s40477-021-00605-8

APA

Skaarup, K. G., Lassen, M. C. H., Espersen, C., Lind, J. N., Johansen, N. D., Sengeløv, M., Alhakak, A. S., Nielsen, A. B., Ravnkilde, K., Hauser, R., Schöps, L. B., Holt, E., Bundgaard, H., Hassager, C., Jabbari, R., Carlsen, J., Kirk, O., Bodtger, U., Lindholm, M. G., ... Biering-Sørensen, T. (2021). Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study. Journal of ultrasound, 1-11. https://doi.org/10.1007/s40477-021-00605-8

CBE

Skaarup KG, Lassen MCH, Espersen C, Lind JN, Johansen ND, Sengeløv M, Alhakak AS, Nielsen AB, Ravnkilde K, Hauser R, Schöps LB, Holt E, Bundgaard H, Hassager C, Jabbari R, Carlsen J, Kirk O, Bodtger U, Lindholm MG, Wiese L, Kristiansen OP, Walsted ES, Nielsen OW, Lindegaard B, Tønder N, Jeschke KN, Ulrik CS, Lamberts M, Sivapalan P, Pallisgaard J, Gislason G, Iversen K, Jensen JUS, Schou M, Skaarup SH, Platz E, Biering-Sørensen T. 2021. Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study. Journal of ultrasound. 1-11. https://doi.org/10.1007/s40477-021-00605-8

MLA

Vancouver

Author

Skaarup, Kristoffer Grundtvig ; Lassen, Mats Christian Højbjerg ; Espersen, Caroline ; Lind, Jannie Nørgaard ; Johansen, Niklas Dyrby ; Sengeløv, Morten ; Alhakak, Alia Saed ; Nielsen, Anne Bjerg ; Ravnkilde, Kirstine ; Hauser, Raphael ; Schöps, Liv Borum ; Holt, Eva ; Bundgaard, Henning ; Hassager, Christian ; Jabbari, Reza ; Carlsen, Jørn ; Kirk, Ole ; Bodtger, Uffe ; Lindholm, Matias Greve ; Wiese, Lothar ; Kristiansen, Ole Peter ; Walsted, Emil Schwarz ; Nielsen, Olav Wendelboe ; Lindegaard, Birgitte ; Tønder, Niels ; Jeschke, Klaus Nielsen ; Ulrik, Charlotte Suppli ; Lamberts, Morten ; Sivapalan, Pradeesh ; Pallisgaard, Jannik ; Gislason, Gunnar ; Iversen, Kasper ; Jensen, Jens Ulrik Stæhr ; Schou, Morten ; Skaarup, Søren Helbo ; Platz, Elke ; Biering-Sørensen, Tor. / Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events : the ECHOVID-19 study. I: Journal of ultrasound. 2021 ; s. 1-11.

Bibtex

@article{7cbcb2ea55e54551a3d072cdd038d8ad,
title = "Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study",
abstract = "PURPOSE: Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE).METHODS: A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores).RESULTS: Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses.CONCLUSION: In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. CLINICALTRIALS.GOV ID: NCT04377035.",
keywords = "B-lines, COVID-19, Lung ultrasound, Venous thromboembolic events",
author = "Skaarup, {Kristoffer Grundtvig} and Lassen, {Mats Christian H{\o}jbjerg} and Caroline Espersen and Lind, {Jannie N{\o}rgaard} and Johansen, {Niklas Dyrby} and Morten Sengel{\o}v and Alhakak, {Alia Saed} and Nielsen, {Anne Bjerg} and Kirstine Ravnkilde and Raphael Hauser and Sch{\"o}ps, {Liv Borum} and Eva Holt and Henning Bundgaard and Christian Hassager and Reza Jabbari and J{\o}rn Carlsen and Ole Kirk and Uffe Bodtger and Lindholm, {Matias Greve} and Lothar Wiese and Kristiansen, {Ole Peter} and Walsted, {Emil Schwarz} and Nielsen, {Olav Wendelboe} and Birgitte Lindegaard and Niels T{\o}nder and Jeschke, {Klaus Nielsen} and Ulrik, {Charlotte Suppli} and Morten Lamberts and Pradeesh Sivapalan and Jannik Pallisgaard and Gunnar Gislason and Kasper Iversen and Jensen, {Jens Ulrik St{\ae}hr} and Morten Schou and Skaarup, {S{\o}ren Helbo} and Elke Platz and Tor Biering-S{\o}rensen",
year = "2021",
month = jul,
day = "2",
doi = "10.1007/s40477-021-00605-8",
language = "English",
pages = "1--11",
journal = "Journal of ultrasound",
issn = "1876-7931",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events

T2 - the ECHOVID-19 study

AU - Skaarup, Kristoffer Grundtvig

AU - Lassen, Mats Christian Højbjerg

AU - Espersen, Caroline

AU - Lind, Jannie Nørgaard

AU - Johansen, Niklas Dyrby

AU - Sengeløv, Morten

AU - Alhakak, Alia Saed

AU - Nielsen, Anne Bjerg

AU - Ravnkilde, Kirstine

AU - Hauser, Raphael

AU - Schöps, Liv Borum

AU - Holt, Eva

AU - Bundgaard, Henning

AU - Hassager, Christian

AU - Jabbari, Reza

AU - Carlsen, Jørn

AU - Kirk, Ole

AU - Bodtger, Uffe

AU - Lindholm, Matias Greve

AU - Wiese, Lothar

AU - Kristiansen, Ole Peter

AU - Walsted, Emil Schwarz

AU - Nielsen, Olav Wendelboe

AU - Lindegaard, Birgitte

AU - Tønder, Niels

AU - Jeschke, Klaus Nielsen

AU - Ulrik, Charlotte Suppli

AU - Lamberts, Morten

AU - Sivapalan, Pradeesh

AU - Pallisgaard, Jannik

AU - Gislason, Gunnar

AU - Iversen, Kasper

AU - Jensen, Jens Ulrik Stæhr

AU - Schou, Morten

AU - Skaarup, Søren Helbo

AU - Platz, Elke

AU - Biering-Sørensen, Tor

PY - 2021/7/2

Y1 - 2021/7/2

N2 - PURPOSE: Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE).METHODS: A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores).RESULTS: Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses.CONCLUSION: In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. CLINICALTRIALS.GOV ID: NCT04377035.

AB - PURPOSE: Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE).METHODS: A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores).RESULTS: Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses.CONCLUSION: In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. CLINICALTRIALS.GOV ID: NCT04377035.

KW - B-lines

KW - COVID-19

KW - Lung ultrasound

KW - Venous thromboembolic events

UR - http://www.scopus.com/inward/record.url?scp=85109293785&partnerID=8YFLogxK

U2 - 10.1007/s40477-021-00605-8

DO - 10.1007/s40477-021-00605-8

M3 - Journal article

C2 - 34213740

SP - 1

EP - 11

JO - Journal of ultrasound

JF - Journal of ultrasound

SN - 1876-7931

ER -

ID: 66565591