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Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

Long-term prognostic significance of homocysteine in middle-aged and elderly

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.

METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.

RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.

CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.

OriginalsprogEngelsk
TidsskriftBiomarkers
Vol/bind21
Udgave nummer6
Sider (fra-til)490-6
Antal sider7
ISSN1354-750X
DOI
StatusUdgivet - sep. 2016

ID: 49768627