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Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

Impact of pre-admission depression on mortality following myocardial infarction

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Jens Sundbøll
  • Morten Schmidt
  • Kasper Adelborg
  • Lars Pedersen
  • Hans Erik Bøtker
  • Poul Videbech
  • Henrik Toft Sørensen
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Background The prognostic impact of previous depression on myocardial infarction survival remains poorly understood.AimsTo examine the association between depression and all-cause mortality following myocardial infarction.MethodUsing Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995-2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.ResultsWe identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87%v.78%). The overall aMRR was 1.11 (95% CI 1.07-1.15) increasing to 1.22 (95% CI 1.17-1.27) when including use of antidepressants in the depression definition.ConclusionsA history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.

OriginalsprogEngelsk
TidsskriftThe British journal of psychiatry : the journal of mental science
Vol/bind210
Udgave nummer5
Sider (fra-til)356-361
Antal sider6
ISSN0007-1250
DOI
StatusUdgivet - maj 2017

ID: 52710726