Forskning
Udskriv Udskriv
Switch language
Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

I-MIBG imaging for detection of anthracycline-induced cardiomyopathy

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A reassessment of the blood-brain barrier transport of large neutral amino acids during acute systemic inflammation in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sphenopalatine ganglion stimulation induces changes in cardiac autonomic regulation in cluster headache

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Rubidium-82 positron emission tomography for detection of acute doxorubicin-induced cardiac effects in lymphoma patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. I-123-MIBG for detection of subacute doxorubicin-induced cardiotoxicity in patients with malignant lymphoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Causes of iron overload in blood donors - a clinical study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Positron emission tomography of the vulnerable atherosclerotic plaque in man--a contemporary review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Non-invasive imaging for subclinical coronary atherosclerosis in patients with peripheral artery disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Due to improvements in early detection and treatment of malignant disease, the population of cancer survivors is constantly expanding. Cancer survivors are faced with chemotherapy-related long-term side effects, including irreversible cardiac injury with risk of heart failure (HF). Numerous antineoplastic regimens are associated with risk of cardiac side effects, but anthracyclines in particular carry a severe risk of cardiotoxicity. Currently, serial echocardiographic evaluation of resting left ventricular ejection fraction (LVEF) is the gold standard for monitoring anthracycline-induced cardiac side effects from chemotherapy. LVEF measurements are, however, limited by their low sensitivity. A normal LVEF does not exclude cardiotoxicity and declines in LVEF are usually not observed before the occurrence of irreversible cardiomyopathy. Hence, a clinically applicable high-sensitivity diagnostic tool for early detection of chemotherapy-related cardiotoxicity is still lacking and alternative non-invasive imaging modalities are therefore being investigated.123I-MIBG is a noradrenaline (NA) analogue used for evaluation of cardiac adrenergic function, including assessment of HF prognosis and evaluation of HF treatment response. However, the role of123I-MIBG for monitoring chemotherapy-related cardiotoxicity is still unclear. Here, we review the value of123I-MIBG imaging for early detection and prevention of anthracycline-induced cardiomyopathy.

OriginalsprogEngelsk
TidsskriftClinical Physiology and Functional Imaging
Vol/bind38
Udgave nummer2
Sider (fra-til)176-185
Antal sider10
ISSN1475-0961
DOI
StatusUdgivet - mar. 2018

ID: 52702853