Forskning
Udskriv Udskriv
Switch language
Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

Heritability of resting heart rate and association with mortality in middle-aged and elderly twins

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Risk of out-of-hospital cardiac arrest in patients with bipolar disorder or schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Temporal trends and sex differences in sudden cardiac death in the Copenhagen City Heart Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Global longitudinal strain predicts cardiovascular events after coronary artery bypass grafting

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Serum proatrial natriuretic peptide does not increase with higher systolic blood pressure in obese men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Changes in left atrial structure and function over a decade in the general population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Left atrial strain predicts incident atrial fibrillation in the general population: the Copenhagen City Heart Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Normal values and reference ranges for left atrial strain by speckle-tracking echocardiography: the Copenhagen City Heart Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Early diastolic strain rate in relation to long term prognosis following isolated coronary artery bypass grafting

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Association of fatal myocardial infarction with past level of physical activity: a pooled analysis of cohort studies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Resting heart rate (RHR) possibly has a hereditary component and is associated with longevity. We used the classical biometric twin study design to investigate the heritability of RHR in a population of middle-aged and elderly twins and, furthermore, studied the association between RHR and mortality.

METHODS: In total, 4282 twins without cardiovascular disease were included from the Danish Twin Registry, hereof 1233 twin pairs and 1816 'single twins' (twins with a non-participating co-twin); mean age 61.7 (SD 11.1) years; 1334 (31.2%) twins died during median 16.3 (IQR 13.8-16.5) years of follow-up assessed through Danish national registers. RHR was assessed by palpating radial pulse.

RESULTS: Within pair correlations for RHR adjusted for sex and age were 0.23 (95% CI 0.14 to 0.32) and 0.10 (0.03 to 0.17) for RHR in monozygotic (MZ) and dizygotic (DZ) twin pairs, respectively. Overall, heritability estimates were 0.23 (95% CI 0.15 to 0.30); 0.27 (0.15 to 0.38) for males and 0.17 (0.06 to 0.28) for females. In multivariable models adjusting for age, gender, body mass index, diabetes, hypertension, pulmonary function, smoking, physical activity and zygosity, RHR was significantly associated with mortality (eg, RHR >90 vs 61-70 beats per min: all-cause HR 1.56 (95% CI 1.21 to 2.03); cardiovascular 2.19 (1.30 to 3.67). Intrapair twin comparison revealed that the twin with the higher RHR was significantly more likely to die first and the probability increased with increase in intrapair difference in RHR.

CONCLUSIONS: RHR is a trait with a genetic influence in middle-aged and elderly twins free of cardiovascular disease. RHR is independently associated with longevity even when familial factors are controlled for in a twin design.

OriginalsprogEngelsk
TidsskriftHeart (British Cardiac Society)
Vol/bind104
Udgave nummer1
Sider (fra-til)30-36
Antal sider7
ISSN1355-6037
DOI
StatusUdgivet - jan. 2018

ID: 55740620