Udskriv Udskriv
Switch language
Bispebjerg Hospital - en del af Københavns Universitetshospital

Glucagon Clearance is Preserved in Type 2 Diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Liraglutide preserved insulin secretion in adults with newly diagnosed type 1 diabetes: the NewLira trial

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Vis graf over relationer

Hyperglucagonemia is a common observation in both obesity and type 2 diabetes, and the etiology is primarily thought to be hypersecretion of glucagon. We investigated whether altered elimination kinetics of glucagon could contribute to the hyperglucagonemia in type 2 diabetes and obesity. Individuals with type 2 diabetes and preserved kidney function (8 with and 8 without obesity) and matched control individuals (8 with and 8 without obesity) were recruited. Each participant underwent a 1-hour glucagon infusion (4 ng/kg/min), achieving steady-state plasma glucagon concentrations, followed by a 1-hour wash-out period. Plasma levels, the metabolic clearance rate (MCR), half-life (T½) and volume of distribution of glucagon were evaluated and a pharmacokinetic model was constructed. Glucagon MCR and volume of distribution were significantly higher in the type 2 diabetes group compared to the control group, while no significant differences between the groups were found in glucagon T½ Individuals with obesity had neither a significantly decreased MCR, T½, nor volume of distribution of glucagon. In our pharmacokinetic model, glucagon MCR associated positively with fasting plasma glucose and negatively with body weight. In conclusion, our results suggest that impaired glucagon clearance is not a fundamental part of the hyperglucagonemia observed in obesity and type 2 diabetes.

Udgave nummer1
Sider (fra-til)73-82
Antal sider10
StatusUdgivet - jan. 2022

Bibliografisk note

© 2021 by the American Diabetes Association.

ID: 68600421