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Bispebjerg Hospital - en del af Københavns Universitetshospital
Udgivet

Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

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  • Anne-Sophie Wedell-Neergaard
  • Louise Lang Lehrskov
  • Regitse Højgaard Christensen
  • Grit Elster Legaard
  • Emma Dorph
  • Monica Korsager Larsen
  • Natja Launbo
  • Sabrina Ravn Fagerlind
  • Sidsel Kofoed Seide
  • Stine Nymand
  • Maria Ball
  • Nicole Vinum
  • Camilla Noerfelt Dahl
  • Marie Henneberg
  • Mathias Ried-Larsen
  • Janus Damm Nybing
  • Robin Christensen
  • Jaya Birgitte Rosenmeier
  • Kristian Karstoft
  • Bente Klarlund Pedersen
  • Helga Ellingsgaard
  • Rikke Krogh-Madsen
Vis graf over relationer

Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.

OriginalsprogEngelsk
TidsskriftCell Metabolism
Vol/bind29
Udgave nummer4
Sider (fra-til)844-855.e3
ISSN1550-4131
DOI
StatusUdgivet - 2 apr. 2019

ID: 56346951