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Bispebjerg Hospital - en del af Københavns Universitetshospital
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Degree of ST-segment elevation in patients with STEMI reflects the acute ischemic burden and the salvage potential

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  • Divan Gabriel Topal
  • Thomas Engstrøm
  • Lars Nepper-Christensen
  • Lene Holmvang
  • Lars Køber
  • Henning Kelbæk
  • Jacob Lønborg
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BACKGROUND: ST-segment elevation myocardial infarction (STEMI) is clinically diagnosed by significant ST-segment elevation (STE) in the electrocardiogram (ECG). The importance of the sum of significant ST-segment elevation (∑STE) before primary percutaneous coronary intervention (PPCI) - considered an indicator of the degree of ischemia - is sparse. We evaluated the association of ∑STE before PPCI with respect to area at risk, infarct size and myocardial salvage.

METHODS: A total of 503 patients with STEMI and available cardiac magnetic resonance (CMR) were included. CMR was performed at day 1 (interquartile range [IQR], 1-1) and at follow-up at day 92 (IQR, 88-96). The ECG before PPCI with the most prominent STE was used for analysis.

RESULTS: ∑STE divided into quartiles were progressive linearly associated with area at risk (p < 0.001), final infarct size (p < 0.001) and extent of microvascular obstruction (p < 0.001) and inverse linearly associated with final myocardial salvage (p < 0.001). Similar results were found for linear regression analyses. However, ∑STE was not associated with final myocardial salvage in patients with pre-PCI TIMI (thrombolysis in myocardial infarction) flow 0/1 (p = 0.24) in contrast to patients with pre-PCI TIMI flow 2/3 (p ≤ 0.001).

CONCLUSION: In patients with STEMI presenting within 12 h of symptom onset, the degree of STE in the ECG before PPCI is a marker of the extent of myocardium at risk that in turn affects the infarct size in patients with pre-PCI TIMI flow 0/1, whereas the degree of STE in patients with pre-PCI TIMI flow 2/3 is a marker of the extent of the myocardium at risk as well as myocardial salvage - both affecting the myocardial damage.

OriginalsprogEngelsk
TidsskriftJournal of Electrocardiology
Vol/bind63
Sider (fra-til)28-34
Antal sider7
ISSN0022-0736
DOI
StatusUdgivet - 1 nov. 2020

Bibliografisk note

Copyright © 2020 Elsevier Inc. All rights reserved.

ID: 61898117