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Bispebjerg Hospital - en del af Københavns Universitetshospital

Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Beckey Trinh
  • Merel Peletier
  • Casper Simonsen
  • Peter Plomgaard
  • Kristian Karstoft
  • Bente Klarlund Pedersen
  • Gerrit van Hall
  • Helga Ellingsgaard
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Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified. In this placebo-controlled, non-randomized, participant-blinded crossover study, we use the IL-6 receptor antibody tocilizumab to investigate the role of endogenous IL-6 in regulating systemic energy metabolism at rest and during exercise and recovery in lean and obese men using tracer dilution methodology. Tocilizumab reduces fatty acid appearance in the circulation under all conditions in lean and obese individuals, whereas lipolysis (the rate of glycerol appearance into the circulation) is mostly unaffected. The fact that fatty acid oxidation is unaffected by IL-6 receptor blockade suggests increased re-esterification of fatty acids. Glucose kinetics are unaffected. We find that blocking endogenous IL-6 signaling with tocilizumab impairs fat mobilization, which may contribute to expansion of adipose tissue mass and, thus, affect the health of individuals undergoing anti-IL-6 therapy ( NCT03967691).

TidsskriftCell reports. Medicine
Udgave nummer9
Sider (fra-til)100396
StatusUdgivet - 21 sep. 2021

Bibliografisk note

© 2021 The Authors.

ID: 68349002