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Bispebjerg Hospital - en del af Københavns Universitetshospital
E-pub ahead of print

Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Ulla Knorr
  • Rasmus Ahrens Blom
  • Anja Hviid Simonsen
  • Henrik Enghusen Poulsen
  • Morten Akhøj
  • Julie Forman
  • Steen Gregers Hasselbalch
  • Lars Vedel Kessing
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OBJECTIVE: Patients with neurodegenerative disorders, schizophrenia, and bipolar disorder present with increased oxidative stress markers. Not only is oxidative stress associated with development of disease, but also with increased disease progression and mortality. Oxidative stress reflects an increase in pro-oxidants, which subsequently leads to oxidative modifications of cellular components, such as RNA and DNA. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the valid marker of whole-body RNA and DNA damage, respectively. Recently, cerebrospinal fluid (CSF) oxidative stress markers of RNA damage (8-oxoGuo) have showed both state and trait dependence in patients with bipolar disorder. However, the relation to subjective measures of stress and quality of life (QoL) is unknown.

MATERIALS AND METHODS: This prospective, longitudinal 1-year follow-up case-control study investigated the association between the oxidative stress markers, 8-oxoGuo and 8-oxodG and, perceived stress and QoL in patients with bipolar disorder (n = 86, 51% female) and gender-and-age-matched healthy control (HC) individuals (n = 44, 44% female). Oxidative stress markers obtained in CSF and urine were analysed using ultra-performance liquid chromatography-tandem mass spectrometry. The subjective perception of stress was assessed using the Perceived Stress Scale. Subjective evaluation of QoL was assessed using the World Health Organization Quality of Life questionnaire.

RESULTS AND CONCLUSION: We found that markers of oxidative stress in CSF and urine were not associated with perceived stress and QoL quality in patients with bipolar disorder. However, a putative association between urinary 8-oxoGuo oxidative stress marker for RNA damage and perceived stress in HC encourages further investigations.

OriginalsprogEngelsk
TidsskriftNordic Journal of Psychiatry
Sider (fra-til)1-6
Antal sider6
ISSN0803-9488
DOI
StatusE-pub ahead of print - 29 mar. 2021

ID: 64729552