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Bispebjerg Hospital - en del af Københavns Universitetshospital

Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Line S Bisgaard
  • Christina Christoffersen
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PURPOSE OF REVIEW: In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest.

RECENT FINDINGS: Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy).

SUMMARY: Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.

TidsskriftCurrent Opinion in Lipidology
Udgave nummer3
Sider (fra-til)212-217
Antal sider6
StatusUdgivet - jun. 2019

ID: 58250424