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Bispebjerg Hospital - en del af Københavns Universitetshospital

A novel chronic wound biofilm model sustaining coexistence of Pseudomonas aeruginosa and Staphylococcus aureus suitable for testing of antibiofilm effect of antimicrobial solutions and wound dressings

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  • Xiaofeng Chen
  • Jan Lorenzen
  • Yijuan Xu
  • Monika Jonikaite
  • Ida Clement Thaarup
  • Thomas Bjarnsholt
  • Klaus Kirketerp-Møller
  • Trine Rolighed Thomsen
Vis graf over relationer

Chronic wounds are a large burden to patients and healthcare systems. Biofilm infections in chronic wounds are crucial factors leading to non-healing of wounds. It is important to study biofilm in wounds and to develop effective interventions against wound biofilm. This study presents a novel in vitro biofilm model mimicking infected chronic wounds. The novel layered chronic wound biofilm model uses woundlike media and includes both Pseudomonas aeruginosa and Staphylococcus aureus, which have been identified as the most important pathogens in wounds. The model sustains their coexistence for at least 96 h. Microscopy of the model revealed microbial growth in non-surface attached microcolonies as previously observed in vivo. The model was used to determine log10 -reduction for the use of an antimicrobial solution and antimicrobial dressings (containing silver or honey) showing moderate-to-low antibiofilm effect, which indicates better concordance with the observed clinical performance of this type of treatment than other widely used standard tests.

TidsskriftWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Udgave nummer5
Sider (fra-til)820-829
Antal sider10
StatusUdgivet - 1 sep. 2021

Bibliografisk note

© 2021 The Authors. Wound Repair and Regeneration published by Wiley Periodicals LLC on behalf of The Wound Healing Society.

ID: 70950117