Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression

Jorgensen, A., Köhler-Forsberg, K., Henriksen, T., Weimann, A., Brandslund, I., Ellervik, C., Poulsen, H. E., Knudsen, G. M., Frokjaer, V. G. & Jorgensen, M. B., 16 maj 2022, I: Translational psychiatry. 12, 1, s. 204

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Associations of urinary metabolites of oxidized DNA and RNA with the incidence of diabetes mellitus using UPLC-MS/MS and ELISA methods

Schöttker, B., Larsen, E. L., Weimann, A., Henriksen, T., Brenner, H. & Poulsen, H. E., apr. 2022, I: Free Radical Biology & Medicine. 183, s. 51-59 9 s.

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Exposure to Tramadol During Early Pregnancy and Risk of Spontaneous Abortion or Major Congenital Malformations

Sørensen, A. M. S., Noergaard, M. M., Gotfredsen, D. R., Kjærbye-Thygesen, A., Jimenez-Solem, E., Askaa, B., Poulsen, H. E., Horwitz, H. & Andersen, J. T., apr. 2022, I: Obstetrics and Gynecology. 139, 4, s. 545-553 9 s., 0000000000004714.

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Skeletal muscle adaptations to exercise are not influenced by metformin treatment in humans: secondary analyses of 2 randomized, clinical trials

Pilmark, N. S., Oberholzer, L., Halling, J. F., Kristensen, J. M., Bønding, C. P., Elkjær, I., Lyngbæk, M., Elster, G., Siebenmann, C., Holm, N. F., Birk, J. B. B., Larsen, E. L., Meinild-Lundby, A-K., Wojtaszewski, J. F., Pilegaard, H., Poulsen, H., Pedersen, B. K., Hansen, K. B. & Karstoft, K., mar. 2022, I: Applied Physiology, Nutrition and Metabolism. 47, 3, s. 309-320 12 s.

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Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial

Larsen, E. L., Kjær, L. K., Lundby-Christensen, L., Boesgaard, T. W., Breum, L., Gluud, C., Hedetoft, C., Krarup, T., Lund, S. S., Mathiesen, E. R., Perrild, H., Sneppen, S. B., Tarnow, L., Thorsteinsson, B., Vestergaard, H., Poulsen, H. E., Madsbad, S. & Almdal, T. P., jan. 2022, I: Free Radical Biology & Medicine. 178, s. 18-25 8 s.

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An in silico kinetic model of 8-oxo-7,8-dihydro-2-deoxyguanosine and 8-oxo-7,8-dihydroguanosine metabolism from intracellular formation to urinary excretion

Jorgensen, A., Thygesen, M. B., Kristiansen, U. & Poulsen, H. E., 1 nov. 2021, I: Scandinavian Journal of Clinical and Laboratory Investigation. 81, 7, s. 540-545 6 s.

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Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

Knorr, U., Blom, R. A., Simonsen, A. H., Poulsen, H. E., Akhøj, M., Forman, J., Hasselbalch, S. G. & Kessing, L. V., okt. 2021, I: Nordic Journal of Psychiatry. 75, 7, s. 532-537 6 s.

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The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes: A randomized trial

Søndergård, S. D., Cintin, I., Kuhlman, A. B., Morville, T., Bergmann, M. L., Kjær, L. K., Poulsen, H. E., Giustarini, D., Rossi, R., Dela, F., Helge, J. W. & Larsen, S., sep. 2021, I: Applied Physiology, Nutrition and Metabolism. 46, 9, s. 1133-1142 10 s., 1099.

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Quantification of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydro-guanosine concentrations in urine and plasma for estimating 24-h urinary output

Henriksen, T., Weimann, A., Larsen, E. L. & Poulsen, H. E., 20 aug. 2021, I: Free Radical Biology & Medicine. 172, s. 350-357 8 s.

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Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

Skals, R., Krogager, M. L., Appel, E. V. R., Schnurr, T. M., Have, C. T., Gislason, G., Poulsen, H. E., Køber, L., Engstrøm, T., Stender, S., Hansen, T., Grarup, N., Lee, C. J-Y., Andersson, C., Torp-Pedersen, C. & Weeke, P. E., 18 jun. 2021, I: PLoS One. 16, 6, s. e0252855 e0252855.

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Treatment of Hyperthyroidism Reduces Systemic Oxidative Stress, as Measured by Markers of RNA and DNA Damage

Larsen, C. B., Riis, K. R., Winther, K. H., Larsen, E. L., Ellervik, C., Hegedüs, L., Brix, T. H., Poulsen, H. E. & Bonnema, S. J., 16 jun. 2021, I: The Journal of clinical endocrinology and metabolism. 106, 7, s. e2512-e2520

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Higher systemic oxidatively generated DNA and RNA damage in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

Coello, K., Bøgh, H. L., Stanislaus, S., Kjærstad, H. L., Melbye, S. A., Ormstrup Sletved, K. S., Poulsen, H. E., Vinberg, M. & Kessing, L. V., 20 maj 2021, I: Free Radical Biology & Medicine. 168, s. 226-233 8 s.

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The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes

Sivalingam, S., Larsen, E. L., van Raalte, D. H., Muskiet, M. H. A., Smits, M. M., Tonneijck, L., Joles, J. A., von Scholten, B. J., Zobel, E. H., Persson, F., Henriksen, T., Diaz, L. J., Hansen, T. W., Poulsen, H. E. & Rossing, P., 19 maj 2021, I: Scientific Reports. 11, 1, s. 10624 10624.

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Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study

Sørensen, A. L., Hasselbalch, H. C., Bjørn, M. E., Nielsen, C. H., Cordua, S., Skov, V., Kjær, L., Poulsen, H. E. & Ellervik, C., maj 2021, I: Redox Biology. 41, 7 s., 101895.

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The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the "DOSE-EX" multi-arm parallel-group randomised clinical trial

Lyngbaek, M. P. P., Legaard, G. E., Bennetsen, S. L., Feineis, C. S., Rasmussen, V., Moegelberg, N., Brinkløv, C. F., Nielsen, A. B., Kofoed, K. S., Lauridsen, C. A., Ewertsen, C., Poulsen, H. E., Christensen, R., Van Hall, G., Karstoft, K., Solomon, T. P. J., Ellingsgaard, H., Almdal, T. P., Pedersen, B. K. & Ried-Larsen, M., 1 apr. 2021, I: Trials. 22, 1, s. 244 244.

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Quantification of biotin in plasma samples by column switching liquid chromatography - tandem mass spectrometry

Weimann, A., Plomgaard, P., Hilsted, L. M., Poulsen, H. E. & Larsen, E. L., apr. 2021, I: Scandinavian Journal of Clinical and Laboratory Investigation. 81, 2, s. 127-136 10 s.

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Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

Klein, A. B., Nicolaisen, T. S., Ørtenblad, N., Gejl, K. D., Jensen, R., Fritzen, A. M., Larsen, E. L., Karstoft, K., Poulsen, H. E., Morville, T., Sahl, R. E., Helge, J. W., Lund, J., Falk, S., Lyngbæk, M., Ellingsgaard, H., Pedersen, B. K., Lu, W., Finan, B., Jørgensen, S. B. & 5 flere, Seeley, R. J., Kleinert, M., Kiens, B., Richter, E. A. & Clemmensen, C., 15 feb. 2021, I: Nature Communications. 12, 1, s. 1041 1041.

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Reduction of oxidative stress on DNA and RNA in obese patients after Roux-en-Y gastric bypass surgery-An observational cohort study of changes in urinary markers

Carlsson, E. R., Fenger, M., Henriksen, T., Kjaer, L. K., Worm, D., Hansen, D. L., Madsbad, S. & Poulsen, H. E., 14 dec. 2020, I: PLoS One. 15, 12, s. 1-19 19 s., e0243918.

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Increased oxidative stress with substantial dysregulation of genes related to oxidative stress and DNA repair after laparoscopic colon cancer surgery

Watt, S. K., Hasselbalch, H. C., Skov, V., Kjær, L., Thomassen, M., Kruse, T. A., Burton, M., Poulsen, H. E. & Gögenur, I., dec. 2020, I: Surgical Oncology. 35, s. 71-78 8 s.

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Effects of a highly controlled carbohydrate-reduced high-protein diet on markers of oxidatively generated nucleic acid modifications and inflammation in weight stable participants with type 2 diabetes; a randomized controlled trial

Skytte, M. J., Samkani, A., Astrup, A., Larsen, T. M., Frystyk, J., Poulsen, H. E., Henriksen, T., Holst, J. J., Andersen, O., Madsbad, S., Haugaard, S. B., Krarup, T. & Larsen, E. L., 1 sep. 2020, I: Scandinavian Journal of Clinical and Laboratory Investigation. 80, 5, s. 401-407 7 s.

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Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study

Larsen, E. L., Poulsen, H. E., Michaelsen, C., Kjær, L. K., Lyngbæk, M., Andersen, E. S., Petersen-Bønding, C., Lemoine, C., Gillum, M., Jørgensen, N. R., Ploug, T., Vilsbøll, T., Knop, F. K. & Karstoft, K., sep. 2020, I: Journal of Sports Sciences. 38, 18, s. 2080-2091 12 s.

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Effect of short-acting exenatide administered three times daily on markers of cardiovascular disease in type 1 diabetes: A randomized double-blind placebo-controlled trial

Johansen, N. J., Dejgaard, T. F., Lund, A., Schlüntz, C., Larsen, E. L., Poulsen, H. E., Goetze, J. P., Møller, H. J., Vilsbøll, T., Andersen, H. U. & Knop, F. K., sep. 2020, I: Diabetes, Obesity and Metabolism. 22, 9, s. 1639-1647 9 s.

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Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents

Jørs, A., Lund, M. A. V., Jespersen, T., Hansen, T., Poulsen, H. E. & Holm, J-C., 1 aug. 2020, I: Free Radical Biology & Medicine. 155, s. 81-86 6 s.

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Are remitted affective disorders and familial risk of affective disorders associated with metabolic syndrome, inflammation and oxidative stress? - a monozygotic twin study

Ottesen, N. M., Meluken, I., Frikke-Schmidt, R., Plomgaard, P., Scheike, T., Fernandes, B. S., Berk, M., Poulsen, H. E., Kessing, L. V., Miskowiak, K. & Vinberg, M., jul. 2020, I: Psychological Medicine. 50, 10, s. 1736-1745 10 s.

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Desloratadine Use During Pregnancy and Risk of Adverse Fetal Outcomes: A Nationwide Cohort Study

Andersson, N. W., Poulsen, H. E. & Andersen, J. T., maj 2020, I: The journal of allergy and clinical immunology. In practice. 8, 5, s. 1598-1605 8 s.

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Changes in oxidative nucleic acid modifications and inflammation following one-week treatment with the bile acid sequestrant sevelamer: Two randomised, placebo-controlled trials

Brønden, A., Larsen, E. L., Karstoft, K., Henriksen, T., Vilsbøll, T., Poulsen, H. E. & Knop, F. K., feb. 2020, I: Journal of Diabetes and its Complications. 34, 2, 107446.

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The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial

van Bommel, E. J. M., Muskiet, M. H. A., van Baar, M. J. B., Tonneijck, L., Smits, M. M., Emanuel, A. L., Bozovic, A., Danser, A. H. J., Geurts, F., Hoorn, E. J., Touw, D. J., Larsen, E. L., Poulsen, H. E., Kramer, M. H. H., Nieuwdorp, M., Joles, J. A. & van Raalte, D. H., 1 jan. 2020, I: Kidney International. 97, 1, s. 202-212 11 s.

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Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol

Köhler-Forsberg, K., Jorgensen, A., Dam, V. H., Stenbæk, D. S., Fisher, P. M., Ip, C-T., Ganz, M., Poulsen, H. E., Giraldi, A., Ozenne, B., Jørgensen, M. B., Knudsen, G. M. & Frokjaer, V. G., 2020, I: Frontiers in Psychiatry. 11, s. 641 641.

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Cerebrospinal fluid oxidative stress metabolites in patients with bipolar disorder and healthy controls: a longitudinal case-control study

Knorr, U., Simonsen, A. H., Roos, P., Weimann, A., Henriksen, T., Christensen, E-M., Vinberg, M., Mikkelsen, R. L., Kirkegaard, T., Jensen, R. N., Akhøj, M., Forman, J., Poulsen, H. E., Hasselbalch, S. G. & Kessing, L. V., 1 dec. 2019, I: Translational psychiatry. 9, 1, s. 325 325.

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Interventions targeted at oxidatively generated modifications of nucleic acids focused on urine and plasma markers

Larsen, E. L., Weimann, A. & Poulsen, H. E., dec. 2019, I: Free Radical Biology & Medicine. 145, s. 256-283 28 s.

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Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

Jorgensen, A., Breitenstein, K., Kalliokoski, O., Weimann, A., Henriksen, T., Poulsen, H. E., Jorgensen, M. B. & Wörtwein, G., dec. 2019, I: Acta Neuropsychiatrica. 31, 6, s. 287-293 7 s.

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Oxidatively generated modifications to nucleic acids in vivo: Measurement in urine and plasma

Poulsen, H. E., Weimann, A., Henriksen, T., Kjær, L. K., Larsen, E. L., Carlsson, E. R., Christensen, C. K., Brandslund, I. & Fenger, M., dec. 2019, I: Free Radical Biology & Medicine. 145, s. 336-341 6 s.

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The Effect of Different Training Intensities on Oxidatively Generated Modifications of Nucleic Acids: A Randomized, Controlled Trial

Larsen, E. L., Mensberg, P., Knop, F. K. & Enghusen-Poulsen, H., dec. 2019, I: Free Radical Biology and Medicine. 145, Suppl 1, s. 28-29 33.

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Polygenic predisposition to breast cancer and the risk of coronary artery disease

D'Souza, M., Schou, M., Skals, R., Weeke, P. E., Lee, C., Smedegaard, L., Madelaire, C., Gerds, T. A., Poulsen, H. E., Hansen, T., Grarup, N., Pedersen, O., Stender, S., Engstrøm, T., Fosbøl, E., Nielsen, D., Gislason, G., Køber, L., Torp-Pedersen, C. & Andersson, C., 15 sep. 2019, I: International Journal of Cardiology. 291, s. 145-151 7 s.

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Identification and quantification of isoguanosine in humans and mice

Weimann, A., McLeod, G., Henriksen, T., Cejvanovic, V. & Poulsen, H. E., jul. 2019, I: Scandinavian Journal of Clinical and Laboratory Investigation. 79, 4, s. 225-232 8 s.

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Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes

Kofoed Kjær, L., Cejvanovic, V., Henriksen, T., Hansen, T., Pedersen, O., Kjeldahl Christensen, C., Torp-Pedersen, C., Alexander Gerds, T., Brandslund, I., Mandrup-Poulsen, T. & Enghusen Poulsen, H., jun. 2019, I: Free Radical Research. 53, 6, s. 694-703 10 s.

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Clinical, Physiologic, and Behavioral Evaluation of Permanently Catheterized NMRI Mice

Falkenberg, M. K., Teilmann, A. C., Henriksen, T., Hau, J., Poulsen, H. E. & Abelson, K. S., 1 maj 2019, I: Journal of the American Association for Laboratory Animal Science : JAALAS. 58, 3, s. 380-389 10 s.

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A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder

Munkholm, K., Vinberg, M., Pedersen, B. K., Poulsen, H. E., Ekstrøm, C. T. & Vedel Kessing, L., 1 mar. 2019, I: Acta Psychiatrica Scandinavica. 139, 3, s. 227-236 10 s.

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The effect of structured personal care on RNA oxidation: A 19-year follow-up of the randomized trial Diabetes Care in General Practice (DCGP)

Kjaer, L. K., Grand, M. K., Siersma, V., Broedbaek, K., Jorgensen, A., de Fine Olivarius, N. & Poulsen, H. E., mar. 2019, I: Journal of Diabetes and its Complications. 33, 3, s. 202-207 6 s.

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The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: A randomized placebo-controlled study

Ellegaard, P. K., Licht, R. W., Nielsen, R. E., Dean, O. M., Berk, M., Poulsen, H. E., Mohebbi, M. & Nielsen, C. T., 15 feb. 2019, I: Journal of Affective Disorders. 245, s. 1043-1051 9 s.

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Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations

Andersson, C., Lukács Krogager, M., Kuhr Skals, R., Rosenbaum Appel, E. V., Theil Have, C., Grarup, N., Pedersen, O., Jeppesen, J. L., Pedersen, O. D., Dominguez, H., Dixen, U., Engstrøm, T., Tønder, N., Roden, D. M., Stender, S., Gislason, G. H., Enghusen-Poulsen, H., Hansen, T., Køber, L., Torp-Pedersen, C. & 1 flere, Weeke, P. E., 1 feb. 2019, I: PLoS One. 14, 2, e0211690.

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Statin treatment, oxidative stress and inflammation in a Danish population

Sørensen, A. L., Hasselbalch, H. C., Nielsen, C. H., Poulsen, H. E. & Ellervik, C., feb. 2019, I: Redox Biology. 21, s. 101088 101088.

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Exposure to antazoline-naphazoline eye drops during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study

Thomseth, V., Cejvanovic, V., Jimenez-Solem, E., Poulsen, H. E., Utheim, T. P. & Andersen, J. T., 2019, I: Acta Ophthalmologica. 97, 5, s. 505-509 5 s.

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Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue

Nielsen, B., Cejvanovic, V., Wörtwein, G., Hansen, A. R., Marstal, K. K., Weimann, A., Bjerring, P. N., Dela, F., Poulsen, H. E. & Jørgensen, M. B., 2019, I: Neuroscience Letters. 690, s. 1-5

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Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis

Bjørn, M. E., Brimnes, M. K., Gudbrandsdottir, S., Andersen, C. L., Poulsen, H. E., Henriksen, T., Hasselbalch, H. C. & Nielsen, C. H., 2019, I: Leukemia and Lymphoma. 60, 10, s. 2549-2557 9 s.

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Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography

Lukács Krogager, M., Skals, R. K., Appel, E. V. R., Schnurr, T. M., Engelbrechtsen, L., Have, C. T., Pedersen, O., Engstrøm, T., Roden, D. M., Gislason, G., Poulsen, H. E., Køber, L., Stender, S., Hansen, T., Grarup, N., Andersson, C., Torp-Pedersen, C. & Weeke, P., 19 dec. 2018, I: PLoS One. 13, 12, s. e0208645

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Indicator of RNA oxidation in urine for the Prediction of Mortality in Patients with Type 2 Diabetes and Microalbuminuria: A Post-Hoc Analysis of the Steno-2 Trial

Kjaer, L. K., Oellgaard, J., Henriksen, T., Gaede, P., Pedersen, O. & Poulsen, H. E., dec. 2018, I: Free Radical Biology & Medicine. 129, s. 247-255 9 s.

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RNA oxidation and iron levels in patients with diabetes

Cejvanovic, V., Kjær, L. K., Mørup Bergholdt, H. K., Henriksen, T., Weimann, A., Ellervik, C. & Poulsen, H. E., dec. 2018, I: Free Radical Biology & Medicine. 129, s. 532-536 5 s.

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